Adverse Drug Reaction in 385 Elderly Inpatients with Bacterial Pneumonia under Polypharmacy

doi:10.19803/j.1672-8629.20240645

Abstract

Abstract: Objective To analyze the characteristics of and risk factors for adverse drug reactions (ADR) in elderly inpatients with bacterial pneumonia and treated with polypharmacy. Methods The clinical data of elderly inpatients with bacterial pneumonia treated between January 1, 2018 and November 30, 2022 was retrospectively analyzed. The correlations between drugs and ADR were evaluated using the Naranjo evaluation method while the severity of ADR was graded with Common Terminology Criteria for Adverse Events version 5.0. A logistic regression equation was established using the backward selection method to analyze the risk factors. Results Among the 4 967 elderly inpatients with bacterial pneumonia, there were 464 cases of ADR in 385 of these patients, so the overall incidence rate of ADR was 7.75% that were mostly related to the gastrointestinal system (40.52%), circulatory system (14.44%) and liver function injury(12.28%). A total of 671 related drugs were involved in ADR, such as anti-infective drugs (63.79%), anticoagulants (6.56%) and antiplatelet drugs (6.41%). The severity of ADR was primarily grade 1(30.17%) and grade 2(59.91%). Multivariate logistic regression results showed that days of hospitalization, numbers of medications, drug allergy history, being female, cerebrovascular diseases and connective tissue diseases increased the risk of ADR in patients. Conclusion Clinicians and pharmacists should be alert to ADR in high-risk patients. This study is expected to contribute to the development of risk prediction models of ADR for elderly inpatients with bacterial pneumonia in the future.

Key words: Bacterial Pneumonia, Elderly Patients, Polypharmacy, Gastrointestinal System, Anti-Infective Drugs, Adverse Drug Reaction, Logistic Regression

CLC Number:

R798.1
R743

LIU Biqing, ZHANG Xiaotong, WANG Ke, XING Xiaoxuan, WANG Zhizhou, ZHUANG Wei, ZHANG Qingxia, ZHANG Lan, LI Xiaoling, DONG Xianzhe. Adverse Drug Reaction in 385 Elderly Inpatients with Bacterial Pneumonia under Polypharmacy[J]. Chinese Journal of Pharmacovigilance, 2025, 22(2): 206-210.

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