Abstract: ObjectiveTo analyze the situation of serious adverse drug reaction/event(SADR/SADE) of Iohexol injection and related factors, provide a reference for clinical medication. MethodsLiterature published in CNKI and Wanfang database from January 1998 to March 2012, according to the literature of pre-established inclusion criteria to collect literature, extract and analyze information involving Iohexol injection SADR/SADE. Results25 literatures were adopted, the level of evidence were 3b or 2b, 63 cases were involved and all cases are adults, which mostly middle-aged patients. The main clinical manifestations of SADR/SADE were contrast nephropathy, shock, and allergic-like reaction. ConclusionsWe should strengthen the monitoring of Iohexol injection. The pharmaceutical factories should carry out large-scale epidemiological studies to explore the protective factors and risk factors about Iohexol injection in clinical use, improve the instructions and provide scientific basis to control the risks in clinical use.

Key words: Iohexol Injection, serious adverse drug reaction/event(SADR/SADE), literature analysis