Abstract: Objective To analyze the clinical characteristics of thrombocytopenia caused by quinolones, levofloxacin and moxifloxacin so as to provide reference for clinical safe drug use. Methods By searching PubMed, Medline, CNKI database and VIP Chinese full-text database, case reports of adverse drug reactions of thrombocytopenia induced by levofloxacin and moxifloxacin were retrieved. The patients' gender, age, underlying diseases, combined medication, routes of administration, clinical manifestations and prognosis were also analyzed statistically. Results Totally 10 patients with thrombocytopenia induced by levofloxacin and 6 patients by moxifloxacin were collected. Statistics showed that 62.5% of these adverse reactions occurred in patients over 60 years old. 68.75% of the cases had a history of such preexisting chronic diseases as hypertension and diabetes mellitus. Except for one patient who died, the conditions of other patients improved within 5~40 days of withdrawal. The adverse reactions of this type were severe. Conclusion There are few reports of adverse drug reactions of thrombocytopenia caused by quinolones, but the consequences are serious. Clinical application should be monitored as soon as possible for the sake of symptomatic treatment.

Key words: quinolone, thrombocytopenia, adverse drug reactions, literature analysis