Literature Analysis of Levofloxacin-induced Delirium

doi:10.19803/j.1672-8629.2020.09.18

Abstract

Abstract: Objective To explore the clinical characteristics and related factors of levofloxacin-induced delirium so as to provide reference for rational and safe use of levofloxacin in clinic. Methods Such databases as CNKI, VIP, Wanfang, and PubMed were searched for related articles published since inception. With "levofloxacin", "delirium", "psychosis" or "disorder" as the key words, all the original literature on levofloxacin-induced delirium was selected and the data about the corresponding indicators was extracted and analyzed. Results A total of 712 articles were retrieved. According to the inclusion and exclusion criteria, 46 articles were accepted and 57 cases of delirium induced by levofloxacin were collected, 35 of whom (61.40%) were males and 22 (38.60%) were females. Among these cases of delirium induced by levofloxacin, 29 involved elders above 65 years old (50.88%). Conclusion Despite the low incidence of delirium induced by levofloxacin, the therapeutic effect and mental health of patients are affected, making it necessary to pay attention to the clinical use. When symptoms occur, correct regimens should be adopted without delay.

Key words: levofloxacin, delirium, psychosis, literature analysis

CLC Number:

R994.11

YANG Lei, WANG Fengling, WU Jingwei, LI Jun. Literature Analysis of Levofloxacin-induced Delirium[J]. Chinese Journal of Pharmacovigilance, 2020, 17(9): 631-635.

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