Chinese Journal of Pharmacovigilance ›› 2021, Vol. 18 ›› Issue (9): 894-897.
DOI: 10.19803/j.1672-8629.2021.09.22

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Psychosis Induced by Teicoplanin: A Case Report

SHEN Xiuxiu1, ZHOU Nan2, ZHANG Wei3, ZHANG Jianghong4, LI Youjia5, *   

  1. 1People's Hospital of Dingbian County, Yulin Shaanxi 718600, China;
    2Shaanxi Provincial People's Hospital, Xi'an Shaanxi 710068, China;
    3The First Affiliated Hospital of Air Force Medical University, Xi'an Shaanxi 710032, China;
    4Army 951 Hospital, Korla Xinjiang 841000, China;
    5The Second Hospital Affiliated to Xi'an Jiaotong University, Xi'an Shaanxi 710004, China
  • Received:2020-01-06 Online:2021-09-15 Published:2021-09-18

Abstract: Objective To analyze one case of psychosis induced by teicoplanin in order to call clinical attention to adverse reactions caused by teicoplanin. Methods The process of diagnosis and treatment of a patient with mental disorder in the course of treatment of methicillin-resistant Staphylococcus aureus (MRSA) infection with teicoplanin was analyzed. Through literature review and analysis, the main causes of mental disorder induced by teicoplanin were described. Results This case of psychosis was likely induced by teicoplanin. Conclusion The concentration of teicoplanin among critically ill patients, especially those with hypoalbuminemia, is highly variable. An appropriate dose should be given on the basis of the patient’s weight and albumin so that the adverse reactions caused by high blood concentration could be prevented.

Key words: teicoplanin, adverse drug reaction, psychosis

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