Abstract: Objective To discuss the characteristics of adverse reactions(ARs) induced by different rabies immunoglobulin, in order to prevent and rescue these adverse reactions in time. Methods AR cases induced by rabies immunoglobulin reported in CNKI from 1956 to 2016 were retrieved and analyzed statistically. Results 75 standard literatures were retrieved, a total of 1087 cases. In these statistic cases, there were no significant differences in gender between anti-rabies serum and human rabies immunoglobulin, and most of the patients are under 20 years of age in anti-rabies serum. The adverse reactions of anti-rabies serum had a certain incubation period, up to a week. And the adverse reactions of human rabies immunoglobulin were more than 85.06% within 30 min after injection. There were 986 cases of anti-rabies serum, mainly serum disease. While human rabies immunoglobulin has lower incidence, only 101 cases showed more adverse reactions such as syncope and vasovagal reflections (VVRS). Conclusion The medical staff and the family members of the patients should be combined with the rabies immunoglobulin inoculated with the patients. The response of the patients should be closely observed before and after the inoculation, and rescue measures should be prepared before the vaccination.

Key words: anti-rabies serum, human rabies immunoglobulin, adverse reactions (ARs), literature analysis