Abstract: Objective To investigate and analyze the risk of safe drug use in hospital patients and in order to provide reference for administrating intervention of rational drug use. Methods To mornitor and statistical analyze the case of irrationality during whole range of drug use of all the hospital patients in Respiratory, Cardiology, General Surgery and Orthopedics in the three comprehensive hospital from May to December in 2008 with case survey of epidemiology. Results There were 1 188 cases(24.19%) of irrational drug use in 4 910 patients in the three hospitals. The frequency of problems causing by dosing concentration(308 cases), time separation(214 cases) and Non-indication medication(147 cases) were the top three in all the index. The consequence of correlation factor showed that the half had been personal relation. There were 302 cases(60.85%) of irrational drug use in 473 enforce monitoring cases, and 23.68%(112 cases) were provided by additional index. Conclusion The key of standardize drug use in clinic,was to provide accurate knowledge, reinforce supervision and enhance responsibilities of staff in hospitals.

Key words: Key word: drug use in clinic, action, factor analysis