Abstract: Objective To investigate the influence factors and medical scheme optimization of irregular uterine bleeding during the treatment of different dosage of gestrinone on endometriosis.Methods Clinical data of 160 patients with endometriosis in our hospital from January 2015 to September 2016 were selected. With the random group division method, the 160 patients were divided into twice a week group (54 cases), three times first month group (53 cases) and three times a week group (53 cases), taking medicine every day 1~day 5 of menstrual cramps, 2.5 mg dose at one time. The condition of dose taking, symptom improvement, vaginal bleeding, and other unpleasant symptoms were recorded during treatment. At the same time detected and recorded the liver function, renal function and blood coagulation function before and after treatment. The related risk factors and the regression coefficient were analyzed by the multiple logistic regression analysis.Results ①In contrast to twice a week group and three times a week group, the incidence of irregular uterine bleeding of double dose first month group was the lowest, there were significant differences between three groups (P<0.05). ②Multiple logistic regression analysis showed that the risk of irregular uterine bleeding of twice a week group was 4-fold higher than that in three times first month group and three times a week group. And in contrast to the abnormal ovarian volume, the risk of normal uterine bleeding of the abnormal ovarian volume was 4-fold higher (P<0.05). ③INR, FIB, PT, TT and APTT of three group were increased after treatment but all of them were in normal range, there were also no significant differences between the groups. ④After the treatment of three months, 12 cases of ALT levels were slightly elevated (49 U·L^-1<ALT<100 U·L^-1), 8 cases of them came from three times a week group, 2 cases of them came from twice a week group, the other 2 cases of them came from double dose first month group, the remaining patients had no liver and renal function damage.Conclusion ①Gestrinone is commonly used drugs for the treatment of endometriosis. It is more suitable for endometriosis patients with abnormal ovarian. ②First double dose can significantly decrease the incidence of irregular uterine bleeding after taking the medicine. ③Gestrinone is safe and effective, can reduce economic burden of patients, and it is worth popularizing.

Key words: gestrinone, endometriosis, irregular uterine bleeding