Abstract: Objective To analyze one case of neurotoxicity caused by fluorouracil. Methods One case of acute neurotoxicity was investigated. The cause of neurotoxicity was identified by analyzing the diagnosis and treatment of the patient while the suspected drug was evaluated via causality assessment of adverse event. Results Neurotoxicity in this patient was considered to have been caused by the rising dose of fluorouracil. After subsequent treatment at a reduced dose of fluorouracil, the patient did not experience any more adverse reactions. Conclusion Toxicity can be increased when fluorouracil is used in intraperitoneal perfusion chemotherapy and intravenous chemotherapy at the same time. In order to decrease the risk of toxicity, clinicians ought to prescribe a lower dosage or choose a different drug.

Key words: Fluorouracil, Injection, Intraperitoneal Perfusion Chemotherapy, Neurotoxicity, Metastatic Colorectal Cancer, Adverse Drug Reactions