Research progress in pharmacokinetic interactions of edoxaban

doi:10.19803/j.1672-8629.20230799

Abstract

Abstract: Objective To find out about the mechanism of pharmacokinetic interactions (PK-DDIs) of edoxaban and methods of dose adjustment, and to provide reference for rational drug combinations in clinic. Methods PubMed, Web of Science, CNKI, Wanfang data and VIP databases were searched for literature related to DDIs of edoxaban. The 2021 European Heart Rhythm Association Guidelines, the US Food and Drug Administration (FDA) specifications, the European Union Product Profile (SmPC) and Lexicomp database were also reviewed. The mechanism of PK-DDIs, clinical evidence and recommended dose adjustment methods of different drugs and edoxaban were summarized. Results A total of 69 drugs in 17 categories were involved, including 24 drugs without the need for dose adjustment and 45 drugs that should be prohibited, cautiously used or adjusted in dosage. Conclusion PK-DDIs of edoxaban involve a variety of drugs, and the mechanism is mainly related to CYP3A4 and P-glycoprotein inhibitors/inducers. However, PK data is currently lacking, and more studies are needed to improve and update the strategies for combinations of drugs. In addition, the individual difference and conditions of patients will affect the in vivo process of edoxaban. Research on multiple factors is lacking, so more research is required to provide evidence for clinical rational drug use.

Key words: edoxaban, pharmacokinetics, drug interaction, adverse drug reactions, P-gp, CYP3A4

CLC Number:

R969.3

WU Shiqi, YAN Suying, ZHANG Qingxia. Research progress in pharmacokinetic interactions of edoxaban[J]. Chinese Journal of Pharmacovigilance, 2024, 21(4): 473-480.

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https://www.zgywjj.com/EN/Y2024/V21/I4/473

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