Efficacy Observation of Edaravone Injection Combined with Tongfuxingshen Decoction on the Postoperative Serum Factors and Neurological Function for fhe Patients with Acute Intracerebral Hemorrhage

Abstract

Abstract: Objective To observe the influence of edaravone injection combined with Tongfuxingshen decoction on the postoperative serum factors and neurological function for the patients with acute intracerebral hemorrhage.Methods 108 cases postoperative patients with acute intracerebral hemorrhage were randomly divided into control group, edaravone group and drug combination group ( 36 cases of each group). Patients in the control group were treated with routine therapy. Patients in other two groups were treated with relevant drugs based on the routine therapy for 28 days. Primary outcomes were measured with Glasgow coma scale (GCS) index, efficacy, NIHSS index and Barthel index before and after treatment.Results The results of Kruskal-Walli H analysis showed the clinical effect of combination group was better than other groups. The GCS score and Barthel score of combination group were higher than other groups, and the NIHSS score was the lowest. The TNF-α and MMP-9 levels of combination group were lower than control group and edaravone group (P<0.05). The clinical effect in edaravone group was better than control group (P<0.05). There was no adverse reaction occurred during treatment in any group.Conclusion Edaravone injection combined with Tongfuxingshen decoction contribute to relieve intracerebral damage and intracerebral edema, and promote the prognoses in patients with acute cerebral hemorrhage after mini-invasive surgery.

Key words: edaravone, Tongfuxingshen decoction, acute intracerebral hemorrhage, serum factor, nearological function damage

CLC Number:

R969

ZHANG Xia-zhi ,LIU Xue-wu, ZHANG Fang-lan. Efficacy Observation of Edaravone Injection Combined with Tongfuxingshen Decoction on the Postoperative Serum Factors and Neurological Function for fhe Patients with Acute Intracerebral Hemorrhage[J]. Chinese Journal of Pharmacovigilance, 2017, 14(2): 78-81.

References

[1] Liu Z, Chen Q, Tian D, et al. Clinical significance of dynamic monitoring by transcranial doppler ultrasound and intracranial pressure monitor after surgery of hypertensive intracerebral hemorrhage[J]. Int J ClinExp Med, 2015, 8(7): 11456-11462.
[2] Koga M, Arihiro S, Hasegawa Y, et al. Intravenous nicardipine dosing for blood pressure lowering in acute intracerebral hemorrhage:the Stroke Acute Management with Urgent Risk-factor Assessment and Improvement-Intracerebral Hemorrhage study[J]. J Stroke Cerebrovasc Dis, 2014, 23(10): 2780-2787.
[3] 陈少婷. 中医中风渊源刍议[D]. 广州中医药大学, 2014.
[4] 白雪, 罗钢, 杨思进,等. 蛭龙活血通瘀胶囊结合中医辨证治疗缺血性中风急性期30例临床观察[J]. 中医杂志, 2014, 55(9): 768-771.
[5] 王文志, 李迪. 中国脑血管病一级预防指南2015要点预览[J]. 中华医学信息导报, 2015, 30(8): 20.
[6] 蒲国明. 活血化瘀汤治疗急性脑出血的临床疗效及对血清超敏C反应蛋白水平、血浆S100β蛋白水平的影响研究[J]. 实用心脑肺血管病杂志, 2016, 24(2): 91-93.
[7] Schaefer P W, Pulli B, Copen W A, et al. Combining MRI with NIHSS Thresholds to Predict Outcome in Acute Ischemic Stroke: Value for Patient Selection.[J]. American Journal of Neuroradiology, 2014, 36(2): 259-264.
[8] Liu N, Cadilhac D A, Andrew N E,et al. Randomized controlled trial of early rehabilitation after intracerebral hemorrhage stroke: difference inoutcomes within 6 months of stroke[J]. Stroke, 2014, 45(12): 3502-3507.
[9] 崔金涛, 柳健雄. 中西医结合治疗高血压急性脑出血研究进展[J]. 湖北中医药大学学报, 2014, 16(1): 115-117.
[10] 许化致, 陈伟建, 王美豪,等. CT灌注成像评价急性自发性高血压脑出血患者的近期预后[J]. 中国医学影像技术, 2012, 28(12): 2132-2135.
[11] 王士强, 张琦辉, 宋同均,等. 脑出血术后应用依达拉奉疗效分析[J]. 中国实用医药, 2015, 10(17): 41-42.
[12] 荣传平, 袁建喜, 陈嘉敏. 通腑醒神汤治疗缺血性脑卒中临床研究[J]. 中外医学研究, 2013, 11(25): 18-19.
[13] 刘惠杰, 徐寅平, 顾兆一,等. 化痰通腑法治疗中风病急性期痰热腑实证105例临床观察[J]. 中国中医基础医学杂志, 2015, 21(5): 616-618.
[14] 代全德, 司金春, 徐忠海,等. 急性脑出血患者血清炎症因子和氧化应激产物的动态监测及其临床意义[J]. 中华临床医师杂志:电子版, 2014,8(3): 39-43.
[15] Alexey E, Pavithra S, Rama S. Verma, et al. IL-6, IL-8, MMP-2, MMP-9 are overexpressed in Fanconi anemia cells through a NF-κB/TNF-α dependent mechanism[J]. Molecular Carcinogenesis, 2014, 54(12): 1686-1699.