Herbal textual research and adverse reaction study of Coprinus comatus

doi:10.19803/j.1672-8629.20240052

Abstract

Abstract: Objective Exploring the medication history and modern research progress of the medicinal fungus Coprinus comatus, providing reference for further research and application of C. comatus. Methods By consulting ancient herbal monographs, we conducted research on the name, origin, morphology, medicinal properties, and efficacy of C. comatus, and conducted in-depth exploration in combination with modern literature research. Results C. comatus has a long history of being used in medicine. The ancient names of C. comatus were Gui Gai, Di Gai, Gui Wu. C. comatus and shaggy mane were the modern names of C. comatus. C. comatus was sweet in properties, flat in tastes, and distributed to stomach and heart meridian tropisms. It is used in the treatment of children's cold and feverish epilepsy, boils and swollen poisons, malignant sores, and centipede, snake and scorpion injuries. Modern pharmacological studies had shown that C. comatus had pharmacological effects such as antioxidant, anticancer, hepatoprotective, anti-inflammatory, antidiabetic, antimicrobial, antiviral, and antinematode activity. Through a systematic review of ancient and modern literature, it was found that C. comatus may cause adverse reactions such as disulfiram-like reaction, gastroenteritis-type poisoning, skin reactions in atopic dermatitis patients, and heavy metal enrichment. Conclusion This article provides a basis for the safe utilization of C. comatus by summarizing the herbal research and adverse reactions of C. comatus.

Key words: Coprinus comatus, Shaggy mane, herbal textual research, disulfiram-like reaction, pharmaceutical security, adverse reaction

CLC Number:

GAO Haiyun, CHEN Yuxin, LI Yao, LI Hui, LIU Tianrui, YUAN Yuan. Herbal textual research and adverse reaction study of Coprinus comatus[J]. Chinese Journal of Pharmacovigilance, 2024, 21(5): 502-506.

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