Abstract: Objective To study the clinical manifestation of clozapine poisoning and discuss the relationship of clozapine blood concentration and hemoperfusion, so as to reduce clozapine poisoning and provide better rescue measures. Methods Clinical data of 22 patients who took clozapine were collected and analyzed in terms of patients' age, dosage, medical test results and hemoperfusion effect. Results After treatment, 13.6% patients were cured, 86.4% patients were improved. After hemoperfusion, the blood concentration of clozapine declined(280.8±180.2) ng·mL-1, and there is a significant difference before and after hemoperfusion(P<0.05). Besides, the time needed for waking of perfusion group and non-perfusion group was (25.8±1.5) h and (34.8±4.1)h respectively(P<0.05). Conclusion All the children poisoned were accidental, clinical pharmacist should explain and publicize the safety way to preserve drugs, and avoid poisoning accidents. In this study, clinical doctors can make a decision to take hemoperfusion measures timely according to blood concentration of clozapine and clinical manifestation, reduce the time needed for waking of patients.

Key words: Key words：clozapine, poisoning, hemoperfusion, children