Research on toxins, poisoning features and exploitation and utilization of Amanita

doi:10.19803/j.1672-8629.20240123

Abstract

Abstract: Objective To explore types of toxins, poisoning features and future utilization in the areas of medicine and biology, provide a new perspective for an objective understanding of Amanita safety, as well as references for further rational development and security applications of Amanita. Methods Based on the relevant literature in China and abroad, the present study of poisoning features, exploitation and utilization of toxins in Amanita were categorized, analyzed and summarized. Results Amanita mainly contains toxic components such as peptides, amino acids, and alkaloids, which are affected by the species, the application site and a variety of factors, resulting in a great difference in the composition and content. Main poisoning features of Amanita are gastrointestinal symptomsand acute liver and kidney injury. Meantime, these toxic components also have development and utilization value in the development of antibacterial, anti-tumor, anti-inflammatory and other drugs and play important roles in life science researches. Conclusion Amanita has important development value, toxic compositions types and mechanisms and safe dosages of Amanita are clarified to provide reference for the development and safe clinical utility.

Key words: Amanita, amatoxin, toxins, poisoning features, virulent, resource development

CLC Number:

R994.11

CHEN Yuxin, LI Yao, GAO Haiyun, LI Hui, LIU Tianrui, YUAN Yuan. Research on toxins, poisoning features and exploitation and utilization of Amanita[J]. Chinese Journal of Pharmacovigilance, 2024, 21(5): 496-501.

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References

[1] CUI YY, CAI Q, TANG LP, et al.The family Amanitaceae: molecular phylogeny, higher-rank taxonomy and the species in China[J]. Fungal Diversity, 2018, 91(1): 5-230.
[2] YANG ZL.Atlas of the Chinese Species of Amanitaceae(中国鹅膏科真菌图志)[M]. Beijing: Science Press, 2015.
[3] HU W, LI Z, WANG W, et al.Structural characterization of polysaccharide purified from Amanita caesarea and its pharmacological basis for application in Alzheimer's disease: endoplasmic reticulum stress[J]. Food Funct, 2021, 12(21): 11009-11023.
[4] LUO Y, YUAN XH, GAO P.Chemical constituents from fruiting bodies of Amanita caesarea[J]. Journal of Chinese Medicinal Materials(中药材), 2016, 39(1): 107-109.
[5] NIAZI A, NAZ H, SHAFIQUE M, et al.Mycochemical screening and study of medicinal properties of two Amanita species (agaricomycetes) from Pakistan[J]. International Journal of Medicinal Mushrooms, 2021, 23(5): 33-39.
[6] SUN L, LIU Q, BAO C, et al.Comparison of free total amino acid compositions and their functional classifications in 13 wild edible mushrooms[J]. Molecules (Basel, Switzerland), 2017, 22(3): E350.
[7] ZHONG XL, ZHONG XY, LIN LJ, et al.Analyses of genomic characteristics and odor substances of strain WPAS01 of Amanita sinensis[J]. Edible Fungi of China(中国食用菌), 2022, 41(8): 43-49.
[8] ŠTEFÁNIKOVÁ J, MARTIŠOVÁ P, ŠNIRC M, et al. The Effect of Amanita rubescens pers developmental stages on aroma profile[J]. Journal of Fungi (Basel, Switzerland), 2021, 7(8): 611.
[9] BISWAS PR, CHATTOPADHYAY P, NANDI S, et al.Investigation of antioxidant activity, myco-chemical content, and GC-MS based molecular docking analysis of bioactive chemicals from Amanita konajensis (agaricomycetes), a tribal myco-food from India[J]. Int J Med Mushrooms, 2024, 26(1): 27-44.
[10] LEE S, ALISHIR A, KIM T, et al.Amanita hemibapha first chemical investigation of Korean wild mushroom, subsp. and the identification of anti-compounds[J]. Pharmaceuticals(Basel, Switzerland), 2022, 15(2): 152.
[11] SURAYOT U, WANGTUEAI S, YOU S, et al.Amanita hemibaphasulphation and hydrolysis improvements of bioactivities, and immuno-modulatory properties of edible subspecies (corner and bas) mucilage polysaccharide as a potential in personalized functional foods[J]. Journal of Fungi(Basel, Switzerland), 2021, 7(10): 847.
[12] LI H, ZHANG Y, ZHANG H, et al.Mushroom poisoning outbreaks - China, 2023[J]. China CDC Wkly, 2024, 6(4): 64-68.
[13] LI HJ, ZHANG YZ, LIU ZT, et al.Species diversity of poisonous mushrooms causing poisoning incidents in Yunnan province, Southwest China[J]. Mycosystema(菌物学报), 2022, 41(9): 1416-1429.
[14] ZHONG J, YAO Q, LI H, et al.Amanita exitialis poisoning in five patients[J]. Clinical Toxicology, 2023, 61(5): 408-409.
[15] YU CM, MEI W, ZHANG YP, et al.Autopsy report of a case of Amanita exitialis poisoning[J]. Chinese Journal of Diagnostic Pathology(诊断病理学杂志), 2020, 27(10): 740-743.
[16] ZUO RL, YANG CA, SHI Y, et al.Treatment of group Amanita exitialis poisoning[J]. West China Medical Journal(华西医学), 2023, 38(11): 1662-1665.
[17] DENG WQ, LI TH, ZHANG M, et al.Analysis of common poisonous species of Amanita and their poisoning cases in south China[J]. Mycosystema(菌物学报), 2020, 39(9): 1750-1758.
[18] ZHANG QY, CHEN ZH, ZHANG CL, et al.An investigation and analysis of four mushroom poisoning cases occurred in Guiyang, Hunan province[J]. Practical Preventive Medicine(实用预防医学), 2003(1): 12-13.
[19] CHEN LP, ZHAO J, LI HJ, et al.Epidemiologic investigation of a mushroom food poisoning incident caused by Amanita fuligineoides[J]. Strait Journal of Preventive Medicine(海峡预防医学杂志), 2023, 29(4): 90-93.
[20] DUAN LF, CHEN LQ, LIU H, et al.Investigation and disposal of a case of mushroom poisoning caused by Amanita fuligineoides[J]. Strait Journal of Preventive Medicine(海峡预防医学杂志), 2022, 28(4): 79-81.
[21] CAI Q, CUI YY, YANG ZL.Lethal Amanita species in China[J]. Mycologia, 2016, 108(5): 993-1009.
[22] ZHU Z, CHEN ZH, ZHOU P, et al.Investigation of a mushroom poisoning incident caused by Amanita pallidorosea[J]. China Preventive Medicine Journal(预防医学), 2016, 28(7): 719-720.
[23] SUN YB, CAO RM, LIU SH, et al.Investigation of a poisoning incident caused by Amanita pallidorosea[J]. Preventive Medicine Tribune(预防医学论坛), 2012, 18(10): 778-779, 782.
[24] CAO RM, LIU Z, ZHANG J, et al.Disposal report of a case of mushroom poisoning caused by Amanita pallidorosea[J]. Journal of Shandong University(Health Sciences)(山东大学学报医学版), 2011, 49(12): 160-162, 164.
[25] XIONG JH, LIU M.Treatment of split skin goose cream and its prognostic factors[J]. Chinese Community Doctors(中国社区医师), 2017, 33(32): 83-84.
[26] CHEN L, TIAN MN, NIU B, et al.Investigation on poisoning by mistaken eating of Amanita subjunquillea in Hebei province[J]. Chinese Journal of Food Hygiene(中国食品卫生杂志), 2018, 30(2): 204-207.
[27] ZHOU YJ, YU H, ZHU Z, et al.Investigation and study on a poisoning incident caused by Amanita subpallidorosea, a new lethal mushroom described from China[J]. Chinese Journal of Food Hygiene(中国食品卫生杂志), 2018, 30(5): 497-501.
[28] ZHAO MF.Clinical analysis of 26 cases of Amanita virosa poisoning[J]. Anhui Medical Journal(安徽医学), 2003, 24(1): 44-45.
[29] CHEN XL, MU SC, WEI RK, et al.Investigation of poisoning of five people caused by Amanita virosa[J]. Guangxi Medical Journal(广西医学), 1992, 14(5): 374-375.
[30] ZHANG ZG, LIU JQ, CHEN ZH, et al.THE investigation of 36 accidents by poisonous mushroom in Hunan[J]. Modern Preventive Medicine(现代预防医学), 2002, 29(3): 301-302, 304.
[31] ZHU KJ, CAI ZH, JI RG.Investigation on a case of poisoning death of four people caused by mistaken eating of mushroom[J]. Chinese Preventive Medicine(中国预防医学杂志), 2002, 3(3): 77.
[32] LI ST, LIU YR, FENG Y, et al.Clinical characteristics of Amanita mushroom poisoning[J]. Journal of Practical Shock(实用休克杂志), 2021, 5(2): 98-100, 104.
[33] MA CM, PENG AH, CAO Y.Research progress of amanitin-containing mushroom poisoning[J]. West China Medical Journal(华西医学), 2023, 38(11): 1748-1754.
[34] DAHIYA S, DAHIYA R, FULORIA NK, et al.Natural bridged bicyclic peptide macrobiomolecules from celosia argentea and Amanita phalloides[J]. Mini Rev Med Chem, 2022, 22(13): 1772-1788.
[35] BHAMBRI A, SRIVASTAVA M, MAHALE VG, et al.Mushrooms as potential sources of active metabolites and medicines[J]. Front Microbiol, 2022, 13: 837266.
[36] CAI Q, TULLOSS RE, TANG LP, et al.Multi-locus phylogeny of lethal amanitas: implications for species diversity and historical biogeography[J]. BMC Evolutionary Biology, 2014, 14: 143.
[37] QIN Q, TIAN EJ, BAO HY.The classification and structures of mushroom toxins[J]. Journal of Fungal Research(菌物研究), 2022, 20(2): 128-140.
[38] WEI JH, WU JF, CHEN J, et al.Identification and content difference of toxic peptides in 12 kinds of lethal amanita species[J]. Chinese Journal of Analytical Chemistry(分析化学), 2017, 45(6): 817-823.
[39] TANG S, ZHOU Q, HE Z, et al.Cyclopeptide toxins of lethal amanitas: compositions, distribution and phylogenetic implication[J]. Toxicon: Official Journal of the International Society on Toxinology, 2016, 120: 78-88.
[40] CHU JZ, CUI Q, YANG SD, et al.Research progress on toxicity mechanism of mushroom toxins[J]. Chinese Traditional and Herbal Drugs(中草药), 2022, 53(24): 7925-7932.
[41] POLIWODA A, ZIELIŃSKA K, HALAMA M, et al. Determination of muscimol and ibotenic acid in mushrooms of Amanitaceae by capillary electrophoresis[J]. Electrophoresis, 2014, 35(18): 2593-2599.
[42] SU Y T, LIU J, YANG DN, et al.Determination of ibotenic acid and muscimol in species of the genus Amanita section Amanita from China[J]. Toxicon, 2023, 233: 107257.
[43] WU FX.Determination of muscarine,ibotenic acid, muscimol and psilocin in common poisonous mushrooms in Yunnan province by UPLC-Q-TOF[D]. Kunming: Kunming Medical University, 2020.
[44] VOYNOVA M, SHKONDROV A, KONDEVA-BURDINA M, et al.Toxicological and pharmacological profile of Amanita muscaria (L.) Lam.- a new rising opportunity for biomedicine[J]. Pharmacia, 2020, 67(4): 317-323.
[45] JI RQ.Research on inhibiting substance of Amanita virosa and its inhibiting mechanism on cylospora chrysosperma[D]. Harbin: Northeast Forestry University, 2007.
[46] WANG YL, BAO HY, XU L, et al.Determination of the major peptide toxins of Amanita pallidorosea by HPLC and inhibitory activity against Blastomyces albicans[J]. Acta Microbiologica Sinica(微生物学报), 2011, 51(9): 1205-1211.
[47] LIU ZC, LI ZX, ZHANG Y, et al.Interpretation on the report of global cancer statistics 2020[J]. Journal of Multidisciplinary Cancer Management(Electronic Version)(肿瘤综合治疗电子杂志), 2021, 7(2): 1-14.
[48] VAN DJK, XU HC, LI YJ, et al.Drug resistance and new therapies in colorectal cancer[J]. World Journal of Gastroenterology, 2018, 24(34): 3834-3848.
[49] XUE J, LOU X, NING D, et al.Mechanism and treatment of α-amanitin poisoning[J]. Arch Toxicol, 2023, 97(1): 121-131.
[50] LI Y, SUN Y, KULKE M, et al. Targeted immunotherapy for HER2-low breast cancer with 17p loss[J]. Science Translational Medicine, 2021, 13(580): eabc6894.
[51] WANG H, BAO HY.Antitumor activity research of phalloidin(PHD)from Amanita subjunquillea[J]. Journal of Fungal Research(菌物研究), 2010, 8(1): 48-51.
[52] LI Y, HSU D, LIU C, et al.The protective effect of muscimol against systemic inflammatory response in endotoxemic mice is independent of GABAergic and cholinergic receptors[J]. Canadian Journal of Physiology and Pharmacology, 2022, 100(7): 665-678.
[53] TANABE T, FUKUDA Y, KAWASHIMA K, et al.Transcriptional inhibition of feline immunodeficiency virus by alpha-amanitin[J]. The Journal of Veterinary Medical Science, 2021, 83(1): 158-161.
[54] WANG F, FAN YJ.Antibacterial and insecticidal activity of five toxic fungal extracts from Changbai mountain[J]. Jiangsu Agricultural Sciences(江苏农业科学), 2015, 43(3): 126-129.
[55] LI J, HUANG Y, WANG D, et al.Comparison of toxic effects of 5 macrofungi against Drosophila melanogaster[J]. J Insect Sci, 2023, 23(3): 20.
[56] JOHNSTON G.Muscimol as an ionotropic GABA receptor agonist[J]. Neurochemical Research, 2014, 39(10): 1942-1947.
[57] LEE M, DUKAN E, MILNE I.Amanita muscaria (fly agaric): from a shamanistic hallucinogen to the search for acetylcholine[J]. The Journal of the Royal College of Physicians of Edinburgh, 2018, 48(1): 85-91.
[58] QIAN SS, LIU MY, RONG R, et al.Research progress in chemical constituents, pharmacology and toxicology of volatile oil in asarum[J]. Chinese Journal of Pharmacovigilance(中国药物警戒), 2021, 18(4): 388-395.