Chinese Journal of Pharmacovigilance ›› 2015, Vol. 12 ›› Issue (9): 567-569.

Previous Articles     Next Articles

Anticoagulation Effect and Association Analysis in Patients on Routine Warfarin Dosage

ZHANG Ya-tong1, FU Chun-yi2, LI Zheng1, DONG Fan1, HU Xin1   

  1. 1.Pharmacy Department, Beijing Hospital, Beijing 100730, China;
    2.Emergency Department, Beijing Hospital, Beijing 100730, China
  • Received:2015-03-19 Revised:2015-12-07 Online:2015-09-08 Published:2015-12-07

PDF (PC)

246

Abstract: Objective To Explore the anticoagulant effect and related factors under conventional warfarin dosing regimen. Methods Patients under 3 mg per day without dosage change more than 5 days were included, the coagulation effect of warfarin was analyzed, and the patients' blood samples were collected and tested in VKORCl and CYP2C9 genotypes, and clinical data of them were also collected. Genetic factors and non-genetic factors were statistically analyzed on the effect of warfarin's anticoagulation. Results 52 patients had INR values below 1.8, 22 patients higher than 2.5, only 21 patients had INR values between 1.8 and 2.5 which accounted for 22.11%. Genetic factors and non-genetic factors had no impact on warfarin anticoagulation effect, and only the age was associated with INR values of the patients. Conclusion Most patients under routine warfarin dosage had not reached into the target INR values, and the age was still the important factor on the warfarin anticoagulation effect .

Key words: warfarin, conventional dose, VKORC1, CYP2C9, polymorphism

CLC Number: