Drug-induced Liver Injury Caused by Warfarin

doi:10.19803/j.1672-8629.2021.04.15

Abstract

Abstract: Objective To analyze the characteristics of drug-induced liver injury (DILI) caused by warfarin in Zhejiang Province so as to provide reference for clinical rational drug use. Methods Data on warfarin-caused adverse drug reactions (ADR), especially DILI, that was collected by the Zhejiang Provincial Platform of the national adverse drug reactions monitoring database from January 1, 2010 to August 31, 2019 was analyzed statistically. Results There were 27 cases of DILI caused by warfarin. There were twice as many female patients as male ones, and most of the patients were over 45 years old (92.3%). Conclusion The DILI caused by warfarin deserves attention in clinical practice when it is used together with other drugs, especially those that are likely to cause hepatotoxicity. It is recommended that warfarin be used with caution and liver function be checked regularly.

Key words: warfarin, adverse drug reaction, drug induced liver injury

CLC Number:

R994.1

WU Ting, LYV Xiaoqin. Drug-induced Liver Injury Caused by Warfarin[J]. Chinese Journal of Pharmacovigilance, 2021, 18(4): 365-367.

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