Abstract: ObjectiveTo probe into the general pattern and characteristics of ADRs induced by clozapine so as to provide references for clinic rational use of clozapine. MethodsCombining the literature, review and retrospectively analyze 274 cases induced by clozapine. ResultsADRs induced by clozapine involve thirteen organ-system damage, the major damages are the damage of the hepatobiliary system and abnormal white blood cells and the reticuloendothelial system, which usually manifest as abnormal liver function, leukopenia and neutropenia. ConclusionIt should be strengthened to observe and evaluate the severe ADRs induced by clozapine. And the medication monitoring of clozapine should be enhanced in order to reduce the injury which the drugs bring.

Key words: clozapine, adverse drug reaction, liver damage, leukopenia, neutropenia