Abstract: ObjectiveTo investigate the characteristics and general pattern of the adverse drug reaction(ADR) occurred in our hospital. MethodsA total of 327 ADR cases collected in our hospital from 2008 to 2011 were analyzed statistically in terms of patients' age, sex, drug category, serious ADR, drug combination, ADR involved organs or systems and clinical manifestations, ect. ResultsAmong 327 cases of ADR reports, 60 years old or older is more, accounting for 75 cases(22.94%); ADR caused by antipsychotics in 13 varieties were in the first place, accounting for 263 cases(80.43%); system or organ involved in ADR cases were most frequently reported as central and peripheral nervous system disorders(124 cases, 36.80%). Gastrointestinal system disorders ranked the second place(57 cases, 16.91%). ConclusionAttention should be paid to the ADR monitoring and reporting work, especially serious adverse reaction of the report and monitoring for the rational use of drugs, strengthen the ADR analysis, evaluation, timely intervention and persuation so as to ensure safe drug use.

Key words: adverse drug reactions, report, analysis, antipsychotic drug, gene polymorphism