Abstract: Objective To investigate the adverse drug reaction(ADR) on children in our hospital, and explore the related factors. Methods Retrospective analyses of ADR were performed on the children cases voluntarily submitted by the medical staff of pediatrics in our hospital. Results A total of 266 suspected medicines were involved in 229 ADR cases, among which 170 cases of anti-infective drugs followed by 25 cases of traditional Chinese medicine injection. 61.65% of anti-infective drugs were antibiotics, and 55 cases were the third generation cephalosporin. Intravenous route was the most common routes for ADR. Skin and appendages damage were observed in 66.9% of cases. 167 patients were cured and 62 cases were improved after drug was withdrawn or receiving the appropriate treatment. Conclusion ADRs were related to many factors, and rational use of drugs was needed to reduce the incidence of ADR.

Key words: children, adverse drug reaction, analysis