Research Progress in Drug Interactions Induced by Citrus Herbs

doi:10.19803/j.1672-8629.2021.05.20

Abstract

Abstract: Objective To summarize the recent research progress in drug interactions induced by Citrus herbs in order to gain keen insights into the interactions and related mechanism. Methods By searching CNKI, PubMed and other databases, literature related to drug interactions induced by Citrus herbs and the related mechanism was reviewed. Results Drug interactions induced by Citrus herbs could be divided into pharmacokinetic ones and pharmacodynamic ones according to the mechanism. The former type was related to flavonoids including hesperidin and naringin, and coumarins such as bergamottin. Citrus herbs could influence the pharmacokinetics of such chemical drugs as tacrolimus, ciclosporin, buspirone and omeprazole via drug enzymes including cytochrome P450, and drug transporters including P-glycoprotein. The latter type was characterized by a decrease in adverse reactions and/or an increase in curative effects of combined drugs, especially antineoplastic drugs, which were associated with flavonoids including hesperidin and tangeretin. Conclusion Clinical observation and basic studies on drug interactions induced by Citrus herbs need to be improved to promote rational combined medication in clinical practice.

Key words: Citrus herbs, drug interaction, pharmacokinetic interaction, pharmacodynamic interaction

CLC Number:

R969.2

LYU Jintao, ZHANG Dan, ZHANG Bing, SA Rina, LIN Zhijian, ZHANG Xiaomeng. Research Progress in Drug Interactions Induced by Citrus Herbs[J]. Chinese Journal of Pharmacovigilance, 2021, 18(5): 495-498.

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