Research Progress in Safety of Herb-drug Interactions Mediated by Metabolizing Enzymes and Transporters

doi:10.19803/j.1672-8629.2021.01.04

Abstract

Abstract: Objective To analyze the possible mechanism by which drug metabolizing enzymes and transporters mediate herb-drug interactions (HDIs) and causes of adverse reactions,and summarize the data about potential interactions between commonly used herbs and conventional chemical drugs.Methods Such databases as PubMed,Web of Science and CNKI were searched with "herbs" "transporters" and "metabolizing enzymes" as the key words.Results The use of herbs combined with chemical drugs was not always conducive and safe.Herbs can mediate the activity of drug metabolic enzymes and transporters to produce HDIs,which can potentially lead to risks of adverse reactions.Conclusion Inappropriate combination of herbs and drugs will increase the chance of potential adverse reactions,and adverse reactions caused by herb-drug interactions deserve the attention of clinicians,pharmaceutical companies and drug regulators.

Key words: herb, drug metabolizing enzymes, transporters, herb-drug interactions(HDIs), nuclear receptor

CLC Number:

R969.2

WANG Shuting, QIU Caixia, WANG Fenglin, JIN Hongtao. Research Progress in Safety of Herb-drug Interactions Mediated by Metabolizing Enzymes and Transporters[J]. Chinese Journal of Pharmacovigilance, 2021, 18(1): 18-23.

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