抑郁症代谢组学及中药调控机制的研究进展

doi:10.19803/j.1672-8629.20250012

摘要/Abstract

摘要： 目的探讨代谢产物参与抑郁症发病的机制及中药调控干预治疗抑郁症的研究进展。方法讨论抑郁症患者差异代谢产物的变化趋势,及中药对抑郁症患者代谢产物和代谢通路的影响。结果抑郁症患者差异代谢物主要集中在氨基酸代谢、能量代谢、脂质代谢通路,中药能够通过影响代谢产物和通路,起到抗抑郁作用。结论深入研究抑郁症患者代谢产物及通路的变化,有助于发掘抑郁症的潜在发病机制,中药可以通过调控干预代谢产物及通路而发挥作用。

关键词: 抑郁症, 发病机制, 中药, 代谢产物, 代谢组学, 氨基酸代谢, 能量代谢, 脂质代谢

Abstract: Objective To summarize the research progress in the involvement of metabolites in the pathogenesis of depression and in treatments for depression with traditional Chinese medicine. Methods The way in which differential metabolites changed in patients with depression and the effects of traditional Chinese medicine on metabolites and pathways were explored. Results The differential metabolites in patients with depression were concentrated in such pathways as the metabolism of amino acids, energy, and lipids. Traditional Chinese medicine could combat depression by affecting metabolites and pathways. Conclusion In-depth study of the changes in metabolites and pathways in patients with depression can help explore the potential pathogenesis of depression. Traditional Chinese medicine can serve as antidepressants by bringing about changes in metabolites and pathways.

Key words: Depression, Pathogenesis, Traditional Chinese Medicine, Metabolites, Metabolomics, Amino Acid Metabolism, Energy Metabolism, Lipid Metabolism

中图分类号:

R971

王雪珍, 孙阳, 孙琦, 赵楠, 王琳, 岳佳音, 孟繁浩. 抑郁症代谢组学及中药调控机制的研究进展[J]. 中国药物警戒, 2025, 22(9): 1061-1067.

WANG Xuezhen, SUN Yang, SUN Qi, ZHAO Nan, WANG Lin, YUE Jiayin, MENG Fanhao. Research Progress in Metabolomics of Depression and Regulatory Mechanisms of Traditional Chinese Medicine[J]. Chinese Journal of Pharmacovigilance, 2025, 22(9): 1061-1067.

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https://zgywjj.magtechjournal.com/CN/Y2025/V22/I9/1061

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