中国药物警戒 ›› 2025, Vol. 22 ›› Issue (3): 258-262.
DOI: 10.19803/j.1672-8629.20240910

• 骨与关节退行性疾病用药安全性研究专栏 • 上一篇    下一篇

痛风合并骨关节炎的中药应用分析

白欣1, 王敏, 王源1, 白建琦1, 苏爽3, 刘广会4, 郭宵飞1, 康佳琪1, 郭东琪1, 张奕萌1, 王浩5, 赵小琪4,*, 张平1#   

  1. 1中国中医科学院望京医院病理科,北京 100102;
    2中国中医科学院望京医院人事处,北京 100102;
    3中国中医科学院望京医院药学部,北京 100102;
    4中国中医科学院望京医院超声科,北京 100102;
    5中国中医科学院望京医院学术发展处,北京 100102
  • 收稿日期:2024-11-25 出版日期:2025-03-15 发布日期:2025-03-17
  • 通讯作者: *赵小琪,女,硕士,肌骨超声研究。E-mail: zxq861019@163.com;#为共同通信作者。
  • 作者简介:白欣,女,在读硕士,中西医结合防治肿瘤。△为并列第一作者。
  • 基金资助:
    国家自然科学基金资助项目（82174415、82405441）;中国中医科学院科技创新工程（CI2021A03307、CI2021A05054）;中国中医科学院望京医院高水平中医医院建设项目中医药临床循证研究专项（WJYY-XZKT-2023-25）

Traditional Chinese Medicine Used in the Treatment of Gout Complicated with Osteoarthritis

BAI Xin1, WANG Min,WANG Yuan1, BAI Jianqi1, SU Shuang3, LIU Guanghui4, GUO Xiaofei1, KANG Jiaqi1, GUO Dongqi1, ZHANG Yimeng1, WANG Hao5, ZHAO Xiaoqi4,*, ZHANG Ping1#   

  1. 1Department of Pathology, Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing 100102, China;
    2Personnel Department, Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing 100102, China;
    3Department of Pharmacy, Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing 100102, China;
    4Department of Ultrasound, Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing 100102, China;
    5Department of Academic Development, Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing 100102, China
  • Received:2024-11-25 Online:2025-03-15 Published:2025-03-17

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摘要： 目的 探析痛风合并骨关节炎的中药应用规律。方法 检索中国中医科学院望京医院信息系统2022年1月1日至2024年9月30日关于痛风合并骨关节炎的门诊病例,提取用药信息后用Microsoft Excel 2016建立数据库,通过古今医案云平台V2.3.7及SPSS Modeler18.0对用药信息进行统计及关联规则分析。结果 纳入病例200例,患者以男性为主,多发于40~49岁。口服中药和外用中药使用频率最高的分别是牛膝和伸筋草,性味均偏好使用温、平、寒性药,甘、苦、辛味药,归经均多集中于肝、肾、脾经,2类中药均以清热、利湿、强筋骨药为主,使用最多的药对分别是黄柏-苍术,海桐皮-伸筋草,联用药物使用最多的是通滞苏润江胶囊。结论 四妙散（苍术、牛膝、黄柏、薏苡仁）、三黄汤（大黄、黄连、黄芩）等经典复方在中医治疗痛风合并骨关节炎中发挥重要作用,中医治疗同时联用成药,为中药治疗痛风合并骨关节炎临床合理应用提供参考。

关键词: 痛风, 骨关节炎, 中药, 临床用药, 四妙散, 三黄汤

Abstract: Objective To study the way in which traditional Chinese medicine is used in treating gout complicated with osteoarthritis. Methods Cases of gout complicated with osteoarthritis were retrieved from the HIS system of Wangjing Hospital of China Academy of Chinese Medical Sciences collected between January 2022 and September 2024. Information about medications was retrieved before a database was established using Microsoft Excel 2016. Statistical analysis and association rule mining were conducted on the information using the Ancient and Modern Medical Records Cloud PlatformV 2.3.7 and SPSS Modeler 18.0. Results A total of 200 cases were included, with a male preponderance and a peak incidence in the 40-49 age group. Achyranthes bidentata and Lycopodium japonicum were the most frequently used oral and external Chinese herbal medicines, respectively. Medications with warm, neutral, and cold properties as well as sweet, bitter, and pungent flavors were preferred. The meridians most frequently targeted were the liver, kidney, and spleen. Both oral and external herbs were primarily used for clearing heat, promoting diuresis, and strengthening muscles and bones. The most commonly used herbal pairs were Cortex Phellodendri-Atractylodes Rhizoma and Erythrina Bark-Lycopodium japonicum, and Tongzhi Surunjiang capsules were the most frequently used combination drug. Conclusion Classical prescriptions such as Simiao powder and Sanhuang decoction play a crucial role in the TCM treatment of gout complicated with osteoarthritis. The concurrent use of proprietary medicines in TCM treatment provides a reference for rational drug use in clinical practice.

Key words: Gout, Osteoarthritis, Traditional Chinese Medicine, Clinical Medication, Simiao Powder, Sanhuang Decoction

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