中国药物警戒 ›› 2025, Vol. 22 ›› Issue (5): 513-516.
DOI: 10.19803/j.1672-8629.20241040

• 中药抗感染作用机制研究专栏 • 上一篇    下一篇

中药干预肺结节用药规律研究

刘莲莲1, 于会勇2, 王明哲3, 郭姗姗4, 李磊2, 高越1, 位式祥1, 柯殷泽1, 王成祥1,*   

  1. 1北京中医药大学第三附属医院呼吸科,北京 100029;
    2北京中医药大学第三附属医院感染科,北京 100029;
    3北京中医药大学东直门医院呼吸科,北京 100700;
    4中国中医科学院中药研究所,道地药材品质保障与资源持续利用全国重点实验室,北京 100700
  • 收稿日期:2024-12-25 出版日期:2025-05-15 发布日期:2025-05-19
  • 通讯作者: *王成祥,男,博士,主任医师,中医药防治呼吸系统疾病。E-mail：wang601@vip.sina.com
  • 作者简介:刘莲莲,女,在读博士,中医药防治呼吸系统疾病。
  • 基金资助:
    国家自然科学基金资助项目（82074389）

TCM Medications for Pulmonary Nodules Based on Traditional Chinese Medicine Inheritance Assistance System

LIU Lianlian1, YU Huiyong2, WANG Mingzhe3, GUO Shanshan4, LI Lei2, GAO Yue1, WEI Shixiang1, KE Yinze1, WANG Chengxiang1,*   

  1. 1Department of Respiratory Diseases, Beijing University of Chinese Medicine Third Affiliated Hospital, Beijing 100029, China;
    2Department of Infectious Diseases, Beijing University of Chinese Medicine Third Affiliated Hospital, Beijing 100029, China;
    3Department of Respiratory Diseases, Dongzhimen Hospital of Beijing University of Chinese Medicine, Beijing 100700, China;
    4State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China
  • Received:2024-12-25 Online:2025-05-15 Published:2025-05-19

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摘要： 目的 运用中医传承辅助系统（V2.5）对北京中医药大学第三附属医院呼吸科门诊治疗肺结节的处方进行数据挖掘分析,探索临床治疗肺结节的用药规律。方法 收集并筛选临床治疗肺结节的有效中药处方,导入系统并进行用药频次统计、中药属性统计、组方规律分析以及新方组合规律分析。结果 共筛选出609份有效中药处方,使用频次≥100次的药物共31味。中药属性分析显示临床处方中使用的药物性味以寒性、苦味药物最多,药物归经以归肺、脾经药物居多。通过用药模式分析得到的核心处方为二陈汤加味,关联规则分析显示浙贝母与清半夏在处方中具有重要地位。新方组合规律分析显示共有5组新方组合。结论 肺结节病机总属中焦失衡、正虚痰毒互结,应以“调脾胃、扶正气、清痰毒”为主要治疗法则,攻补兼施,抑制肺结节增大,为临床治疗肺结节安全合理用药提供参考。

关键词: 肺结节, 中医传承辅助系统, 数据挖掘, 二陈汤加味, 中药复方, 用药规律

Abstract: Objective To conduct data mining analysis of prescriptions for outpatients with pulmonary nodules using the Traditional Chinese Medicine Inheritance Assistance System (V2.5) in order to find out more about what medications are likely used. Methods Clinically effective TCM prescriptions for the treatment of pulmonary nodules were collected and screened before being input into the system for statistical analysis of the frequency of medications, properties of traditional Chinese medicines, and commonly-used compound formulas. Results A total of 609 effective traditional Chinese medicine prescriptions were screened out, and 31 types of TCMs were used more than 100 times. The analysis of properties of traditional Chinese medicines showed that the clinic mostly used cold and bitter medicines in the prescriptions, and most of the drugs targeted the lung and spleen meridians. The analysis of medications suggested that the core prescription proved to be Erchen decoction. The analysis of association rules showed that Bulb of Thunberg Fritillary and Pinellia Ternata were dominating in the prescriptions. The analysis of new compound formulas showed that there were five new combinations. Conclusion The pathogenesis of pulmonary nodules is usually attributed to the imbalanced middle energizer and to the combination of positiveness, deficiency, and phlegmatic toxin. It is recommended that pulmonary nodules be treated by regulating the spleen and stomach, strengthening qi and clearing phlegmatic toxin.

Key words: Pulmonary Nodules, Traditional Chinese Medicine Inheritance Support System, Data Mining, Erchen Decoction, TCM Compound Formulas, Patterns of Medication

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