抗病毒靶点研究和中药活性成分发现进展

doi:10.19803/j.1672-8629.20250099

中国药物警戒 ›› 2025, Vol. 22 ›› Issue (5): 481-487.
DOI: 10.19803/j.1672-8629.20250099

抗病毒靶点研究和中药活性成分发现进展

崔梦瑶, 李舒冉^Δ, 谢丹, 杨晓微, 刘宪, 崔晓兰, 耿子涵^#, 郭姗姗^*

中国中医科学院中药研究所,道地药材与品质保障全国重点实验室,100700

收稿日期:2025-02-17 出版日期:2025-05-15 发布日期:2025-05-19
通讯作者: ^*郭姗姗,女,博士,研究员·博导,中药抗病毒与抗感染药理研究。E-mail: ssguo@icmm.ac.cn;^#为共同通信作者。郭姗姗,研究员,博士生导师;中国中医科学院中药研究所,中药药理研究中心副主任,ABSL-2生物安全实验室主任,中药药理高水平重点学科后备带头人。主要从事中药抗病毒和抗感染药理研究及新药研发。担任国家卫健委高级别实验室生物安全评审专家,中国合格评定国家认可委员会（CNAS）生物安全认可评审专家,世界中医药联合会中医药抗病毒研究专业委员会常务理事,中华中医药学会感染病分会常务委员,中国民族医药学会药理与毒理学分会常务理事。作为负责人承担国家自然科学基金原创探索项目、面上项目、青年基金项目,国家重大新药创制项目,国家重点研发计划,北京市自然基金前沿项目、面上项目,中国博士后基金特别资助项目、面上项目,中国中医科学院科技创新工程重大攻关项目、中国中医科学院自主选题项目等20余项,发表SCI学术论文40余篇、高质量中文核心期刊论文50余篇。获得世界中联中医药国际贡献奖二等奖,中国中医科学院科技进步三等奖。获得全国巾帼建功先进集体（团队带头人）、国家卫健委巾帼建功先进集体奖和中国中医科学院抗击新冠优秀奖、中国中医科学院中药研究所抗疫优秀奖。作为发明人获得专利授权8项。《中国药物警戒》期刊编委。
作者简介:崔梦瑶,女,博士,中药抗病毒与抗炎症研究。^Δ为并列第一作者。
基金资助:
国家科技重大专项（2024D0528801）; 北京市自然科学基金资助项目（7252250、L222130）; 中国中医科学院科技创新工程项目（CI2021A04607）

Research Progress in Antiviral Targets and Active Ingredients of Traditional Chinese Medicine

CUI Mengyao, LI Shuran^Δ, XIE Dan, YANG Xiaowei, LIU Xian, CUI Xiaolan, GENG Zihan^#, GUO Shanshan^*

State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-Di Herbs, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China

Received:2025-02-17 Online:2025-05-15 Published:2025-05-19

1. 抗病毒靶点研究和中药活性成分发现进展_附加材料.docx(235KB)

摘要/Abstract

摘要： 目的阐明中药多成分、多靶点、多通路的整体作用机制,挖掘具有抗病毒作用、抗炎作用、调节免疫作用等活性成分,为研发高效低毒的中药复方制剂提供参考。方法研究总结网络药理学、分子对接技术、高通量药物筛选、整合药理学及结构生物学等现代技术手段在中药抗病毒中的应用研究。总结中药成分与病毒关键蛋白及宿主靶点的结合能力、中药复方的潜在有效成分、靶点调控的分子通路。结果中药的黄酮类、生物碱类、苷类、多糖类、有机酸类化合物等既可以直接作用于入侵和复制的病毒靶点,也可以作用于免疫应答和炎症反应的宿主靶点发挥抗病毒作用。结论中药不仅可以直接杀死病毒,抑制病毒在细胞内的增殖,还可以抑制病毒入侵后所致机体的过度免疫反应。还能调节人体免疫系统,增强人体免疫力,并发挥间接的抗病毒作用,为中药抗病毒药物的筛选提供参考。

关键词: 抗病毒靶点, 宿主靶点, 病毒靶标, 中药活性成分, 免疫应答反应

Abstract: Objective To elucidate the mechanisms of traditional Chinese medicine(TCM) that are characterized by multi-component, multi-target, and multi-pathway interactions, and identify bioactive components with antiviral, anti-inflammatory, and immunomodulatory properties in order to provide references for developing efficient and low-toxicity TCM formulations. Methods Modern techniques, including network pharmacology, molecular docking, high-throughput drug screening, integrative pharmacology, and structural biology, were reviewed to explore their applications in antiviral research on TCM. The binding capacity of TCM components to viral proteins and host targets, potential active ingredients in TCM formulations, and molecular pathways regulated by targets were summarized. Results TCM compounds such as flavonoids, alkaloids, glycosides, polysaccharides, and organic acids exhibited antiviral effects by directly targeting viral invasion/replication-related proteins or modulating host targets involved in immune responses and inflammatory pathways. Conclusion TCM can not only directly inhibit viral proliferation and kill viruses, but also suppress excessive immune reactions post-infection. Additionally, it enhances immunity through immunoregulation, offering indirect antiviral benefits.

Key words: Antiviral Target, Host Target, Viral Target, Herbal Active Ingredient, Immune Response Reaction

中图分类号:

崔梦瑶, 李舒冉, 谢丹, 杨晓微, 刘宪, 崔晓兰, 耿子涵, 郭姗姗. 抗病毒靶点研究和中药活性成分发现进展[J]. 中国药物警戒, 2025, 22(5): 481-487.

CUI Mengyao, LI Shuran, XIE Dan, YANG Xiaowei, LIU Xian, CUI Xiaolan, GENG Zihan, GUO Shanshan. Research Progress in Antiviral Targets and Active Ingredients of Traditional Chinese Medicine[J]. Chinese Journal of Pharmacovigilance, 2025, 22(5): 481-487.

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https://zgywjj.magtechjournal.com/CN/Y2025/V22/I5/481

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抗病毒靶点研究和中药活性成分发现进展

Research Progress in Antiviral Targets and Active Ingredients of Traditional Chinese Medicine

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