中国药物警戒 ›› 2024, Vol. 21 ›› Issue (11): 1243-1249.
DOI: 10.19803/j.1672-8629.20240593

• 生殖功能中医药研究专栏 • 上一篇    下一篇

补肾生精方对少弱精子症潜在防治作用的研究进展

白雪1,2, 陈亚飞3, 唐田4, 刘柘君5, 谭天阳6, 刘振权2,*   

  1. 1中国中医科学院医学实验中心,北京市中医药防治重大疾病基础研究重点实验室,北京 100700;
    2北京中医药大学中药学院,北京 102488;
    3中国中医科学院中医临床基础医学研究所,北京 100007;
    4中国科学院北京基因组研究所,北京 100101;
    5首都医科大学中医药学院,北京 100069;
    6中国中医科学院西苑医院康复医学科,北京 100091
  • 收稿日期:2024-08-15 出版日期:2024-11-15 发布日期:2024-11-20
  • 通讯作者: *刘振权,男,博士,副主任医师·博导,中药防治生殖系统疾病。E-mail: lzqbzy@sina.com
  • 作者简介:白雪,女,博士,助理研究员,中药防治生殖系统疾病。
  • 基金资助:
    国家自然科学基金资助项目（82304767）; 中央级公益性科研院所基本科研业务费专项基金（JJPY2022021和ZZ15-YQ-055）; 中国中医科学院科技创新工程项目（CI2021B017）; 中国中医科学院西苑医院院级师承项目（YJMPSC202437）

Research Progress on the Potential Therapeutic Effect of Bushen Shengjing Prescription on Oligoasthenozoospermia

BAI Xue1,2, CHEN Yafei3, TANG Tian4, LIU Zhejun5, TAN Tianyang6, LIU Zhenquan2,*   

  1. 1Experimental Research Center, China Academy of Chinese Medical Sciences, Beijing Key Laboratory of Traditional Chinese Medicine Basic Research on Prevention and Treatment of Major Disease, Beijing 100700, China;
    2School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, China;
    3Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100007, China;
    4Beijing Institute of Genomics, Chinese Academy of Sciences /China National Center for Bioinformation, Beijing 100101, China;
    5School of Traditional Chinese Medicine, Capital Medical University, Beijing 100069, China;
    6Rehabilitation Medicine Department, Xiyuan Hospital, Chinese Academy of Traditional Chinese Medicine, Beijing 100091, China
  • Received:2024-08-15 Online:2024-11-15 Published:2024-11-20

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摘要： 目的 探讨补肾生精方（BSP）治疗少弱精子症（OA）的潜在防治作用,为后续研究提供理论参考。方法 通过文献回顾,分析BSP中八味中药的药理作用及其在OA治疗中的协同效应。结合已有研究数据,评估BSP对改善精子质量的效果。结果 BSP在治疗OA中显示出良好疗效,可能通过抗氧化、抗炎、抗凋亡等多途径改善精子质量。临床研究初步表明,BSP能够显著提高OA患者的精子活力和数量,从而提高生育能力。结论 BSP在治疗OA方面具有显著的治疗潜力,其多成分、多靶点的作用机制为OA的治疗提供了新的治疗策略。下一步研究应继续验证并深入研究BSP的疗效及作用机制,以促进其在临床上的广泛应用。

关键词: 补肾生精方, 少弱精子症, 进展, 精子质量, 精子活力, 精子数量, 男性不育, 中药

Abstract: Objective To explore the potential therapeutic effects of Bushen Shengjing prescription (BSP) on oligoasthenozoospermia (OA), providing theoretical references for subsequent research. Methods The pharmacological effects of the eight Chinese medicinal herbs in BSP and their synergistic effects in the treatment of OA were analyzed through literature review. The effect of BSP on improving sperm quality was evaluated combined with existing research data. Results BSP has shown good efficacy in the treatment of OA, possibly improving sperm quality through multiple pathways such as antioxidation, anti-inflammation, and anti-apoptosis. Preliminary clinical studies have indicated that BSP can significantly increase the sperm vitality and quantity of OA patients, thereby improving fertility. Conclusion BSP has significant therapeutic potential in the treatment of OA, and its multi-component, multi-target mechanism of action provides a new treatment strategy for OA. Future research should further verify and study the efficacy and mechanism of action of BSP to promote its widespread clinical application.

Key words: Bushen Shengjing Prescription, Oligoasthenozoospermia, Research Progress, Sperm Quality, Sperm Vitality, Sperm Count, Male Infertility, Traditional Chinese Medicine

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