中国药物警戒 ›› 2025, Vol. 22 ›› Issue (3): 349-356.
DOI: 10.19803/j.1672-8629.20240592

• 综 述 • 上一篇    下一篇

安宫牛黄丸临床应用与药理机制研究进展

白雪1,2, 陈亚飞3, 唐田4, 刘柘君5, 王国玉6, 谭天阳2,*   

  1. 1中国中医科学院医学实验中心,北京市中医药防治重大疾病基础研究重点实验室,北京 100700;
    2中国中医科学院西苑医院康复医学科,北京 100091;
    3中国中医科学院中医临床基础医学研究所,北京 100700;
    4中国科学院北京基因组研究所,北京 100101;
    5首都医科大学中医药学院,北京 100069;
    6首都医科大学附属北京世纪坛医院,北京 100038
  • 收稿日期:2024-08-13 出版日期:2025-03-15 发布日期:2025-03-17
  • 通讯作者: *谭天阳,男,博士,主治医师,慢性病康复的机制与临床研究。E-mail: 390985355@qq.com
  • 作者简介:白雪,女,博士,助理研究员,中药防治脑血管疾病。
  • 基金资助:
    国家自然科学基金资助项目（82304767）;中央级公益性科研院所基本科研业务费专项基金（JJPY2022021、ZZ15-YQ-055）;中国中医科学院科技创新工程项目（CI2021B017）;中国中医科学院西苑医院院级师承项目（YJMPSC202437）

Progress in Clinical and Pharmacological Research of Angong Niuhuang Pills

BAI Xue1,2, CHEN Yafei3, TANG Tian4, LIU Zhejun5, WANG Guoyu6, TAN Tianyang2,*   

  1. 1Experimental Research Center, China Academy of Chinese Medical Sciences, Beijing Key Laboratory of Traditional Chinese Medicine Basic Research on Prevention and Treatment of Major Disease, Beijing 100700, China;
    2Rehabilitation Medicine Department, Xiyuan Hospital, Chinese Academy of Traditional Chinese Medicine, Beijing 100091, China;
    3Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China;
    4Beijing Institute of Genomics, Chinese Academy of Sciences/China National Center for Bioinformation, Beijing 100101, China;
    5School of Traditional Chinese Medicine, Capital Medical University, Beijing 100069, China;
    6Beijing Shijitan Hospital Affiliated to Capital Medical University, Beijing 100038, China
  • Received:2024-08-13 Online:2025-03-15 Published:2025-03-17

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摘要： 目的 评估安宫牛黄丸在近3年的临床应用效果及其药理机制,为安宫牛黄丸后续研究提供参考。方法 通过分析最新的临床研究资料,汇总安宫牛黄丸在治疗脑出血、脑梗死、颅脑损伤、热射病、脓毒症、病毒性脑炎、肺炎等多种疾病中的疗效。同时,查阅现代药理研究,分析安宫牛黄丸的药理作用及相关机制。结果 安宫牛黄丸在治疗上述疾病显示出良好疗效。相关药理研究揭示了其通过抗炎、抗氧化、抗凋亡、调节自噬和线粒体功能障碍、抑制焦亡和铁死亡、调节代谢产物和肠道微生物等多种作用机制。结论 综合安宫牛黄丸在多种疾病治疗中的临床效果及其药理作用机制,证实其疗效和多靶点作用特点,为深入研究和临床应用提供参考。

关键词: 安宫牛黄丸, 神经功能, 炎症, 氧化, 凋亡, 临床, 药理, 进展

Abstract: Objective To evaluate the clinical efficacy of Angong Niuhuang pills in the past three years and explore their pharmacological mechanisms in order to provide a reference for subsequent research. Methods By analyzing the latest data on clinical research, the therapeutic effects of Angong Niuhuang pills against such diseases as cerebral hemorrhage, cerebral infarction, craniocerebral injury, heatstroke, sepsis, viral encephalitis and pneumonia were summerized. Additionally, current pharmacological research was reviewed to analyze the mechanisms of action of Angong Niuhuang pills. Results The study found that Angong Niuhuang pills were highly effective in treating the aforementioned diseases. Pharmacological research suggested that they worked through multiple mechanisms, including anti-inflammation, antioxidation, anti-apoptosis, regulation of autophagy and mitochondrial dysfunction, inhibition of pyroptosis and ferroptosis, and regulation of metabolic products and gut microbiota. Conclusion This study has evaluated the clinical efficacy and pharmacological mechanism of Angong Niuhuang pills in the treatment of various diseases and confirmed their therapeutic effect and multi-target characteristics, providing data for subsequent research and clinical applications.

Key words: Angong Niuhuang Pills, Neurological Function, Inflammation, Oxidation, Apoptosis, Clinic, Pharmacology, Progress

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