茯苓酸生物活性与作用机制研究进展

doi:10.19803/j.1672-8629.20240121

摘要/Abstract

摘要： 目的提高对茯苓酸的认知水平以研发其更多潜在价值,并促进茯苓酸的临床应用。方法通过系统文献检索筛选出茯苓酸相关研究,归纳总结茯苓酸的生物活性与作用机制,并对未来研究方向进行预测。结果茯苓酸可从多种天然物中提取,并在多种疾病治疗中展现潜力。其可能通过调节细胞周期、凋亡相关因子及多条信号通路（如NF-κB、Shh/Gli1和JAK2/STAT3/SOCS3）发挥抗肿瘤和抗缺血/再灌注损伤作用。茯苓酸在炎症调节方面也受到关注,可能对肺炎、哮喘、放射性肺炎、结肠炎、膀胱炎和骨关节炎等疾病有重要影响。结论茯苓酸具有显著的生物活性,展现出在抗肿瘤、抗缺血损伤及炎症调节等多种疾病治疗中的潜在应用价值。

关键词: 茯苓酸, 生物活性, 作用机制, 抗肿瘤, 抗缺血损伤, 炎症调节, 研究进展

Abstract: Objective To advance the understanding of pachymic acid in order to explore its potentials and to promote its clinical applications. Methods A systematic literature review was conducted to retrieve studies on pachymic acid. The biological activities and mechanisms of action were summarized while future developments were predicted. Results Pachymic acid could be extracted from various natural sources and demonstrated potentials in the treatment of multiple diseases. It could possibly exert antitumor and anti-ischemic/reperfusion injury effects by modulating the cell cycle, apoptosis-related factors, and several signaling pathways, including NF-κB, Shh/Gli1 and JAK2/STAT3/SOCS3. In addition, pachymic acid garnered attention for its role in inflammation regulation and could potentially impact such conditions as pneumonia, asthma, radiation-induced lung injury, colitis, cystitis, and osteoarthritis. Conclusion Pachymic acid exhibits significant biological activity, revealing its potential applicability in the treatment of various diseases, including tumors, ischemic injury and inflammation.

Key words: Pachymic Acid, Biological Activity, Mechanisms, Tumors, Ischemic Injury, Inflammation, Research Progress

中图分类号:

R961

刘明, 郑丽, 张卫娜, 孙雪林, 田金徽, 赵妍. 茯苓酸生物活性与作用机制研究进展[J]. 中国药物警戒, 2025, 22(7): 826-830.

LIU Ming, ZHENG Li, ZHANG Weina, SUN Xuelin, TIAN Jinhui, ZHAO Yan. Research Progress in Biological Activity and Mechanisms of Pachymic Acid[J]. Chinese Journal of Pharmacovigilance, 2025, 22(7): 826-830.

导出引用管理器 EndNote|Ris|BibTeX

链接本文: https://zgywjj.magtechjournal.com/CN/10.19803/j.1672-8629.20240121

https://zgywjj.magtechjournal.com/CN/Y2025/V22/I7/826

参考文献

[1] DENG D, LIU Y, TANG ZQ, et al.Research Progress on the Regulatory Mechanisms of Pachymic Acid Terpene Biosynthesis[J]. China Journal of Traditional Chinese Medicine and Pharmacy(中华中医药杂志), 2023, 38(9): 4278-4285.
[2] ZHU QS, GAO G, CHEN Q, et al.Quality Control of Triterpenoid Components in Commercial Poria Cocos[J]. West China Journal of Pharmaceutical Sciences(华西药学杂志), 2023, 38(3): 296-299.
[3] XU Y, LIU DG, NING TB, et al.Effects of Poria on Behavioral and Fecal Microbiota in Rats under Mild Chronic Unpredictable Stress[J]. Chinese Journal of Pharmacovigilance(中国药物警戒), 2021, 18(8): 748-752.
[4] DU YH, ZHAO JJ, LI X, et al.Mechanism of Pachymic Acid in the Treatment of Gastric Cancer Based on Network Pharmacology and Experimental Verification[J]. World J Gastrointest Oncol, 2024, 16(1): 30-50.
[5] WU Z, CHEN X, NI W, et al.The Inhibition of Mpro, the Primary Protease of COVID-19, by Poria cocos and Its Active Compounds: a Network Pharmacology and Molecular Docking Study[J]. RSC Adv, 2021, 11: 11821-11843.
[6] YUE S, FENG X, CAI Y, et al.Regulation of Tumor Apoptosis of Poriae Cutis-Derived Lanostane Triterpenes by AKT/PI3K and MAPK Signaling Pathways in vitro[J]. Nutrients, 2023, 15(20): 4360.
[7] HU S, YANG B, LI B, et al.RNA-Seq Analysis Reveals Potential Neuroprotective Mechanisms of Pachymic Acid toward Iron-Induced Oxidative Stress and Cell Death[J]. Cell Transplant, 2024, 33: 9636897231218382.
[8] ZUO J, QI TL, HU XY.Progress in Chemical Constituents and Modern Pharmacological Research of Poria cocos[J]. Acta Chinese Medicine and Pharmacology(中医药学报), 2023, 51(1): 110-114.
[9] WEI C, WANG H, SUN X, et al.Pharmacological Profiles and Therapeutic Applications of Pachymic Acid (Review)[J]. Exp Ther Med, 2022, 24(3): 547.
[10] XU DH, TANG CY, ZHENG H, et al.Research Progress on the Active Component Pachymic Acid in Poria cocos[J]. Food Science, 2022, 43(7): 273-280.
[11] LING Y, CHEN M, WANG K, et al.Systematic Screening and Characterization of the Major Bioactive Components of Poria cocos and Their Metabolites in Rats by LC-ESI-MS(n)[J]. Biomed Chromatogr, 2012, 26(9): 1109-1117.
[12] ZHENG Y, YANG XW.Absorption and Transport of Pachymic Acid in the Human Intestinal Cell Line Caco-2 Monolayers[J]. Journal of Integrative Medicine, 2018, 6(7): 704-710.
[13] WANG FY, LYU WS, HAN L.Determination and Pharmacokinetic Study of Pachymic Acid by LC-MS/MS[J]. Biol Pharm Bull, 2015, 38(9): 1337-1344.
[14] LIU Z, ZHOU W, LIU Q, et al.Pachymic Acid Prevents Hemorrhagic Shock-Induced Cardiac Injury by Suppressing M1 Macrophage Polarization and NF-κB Signaling Pathway[J]. Am J Chin Med, 2023, 51(8): 2157-2173.
[15] SHAH VK, CHOI JJ, HAN JY, et al.Pachymic Acid Enhances Pentobarbital-Induced Sleeping Behaviors via GABAA-Ergic Systems in Mice[J]. Biomol Ther (Seoul), 2014, 22(4): 314-320.
[16] WANG J, YAO N, CHEN Y, et al.Research Progress of cGAS-STING Signaling Pathway in Intestinal Diseases[J]. Int Immunopharmacol, 2024, 135: 112271.
[17] BAI YF.Research on the Mechanisms of Pachymic Acid in the Treatment of Gastric Cancer[D]. Xi’an: Northwest A&F University, 2017.
[18] LIU W, JI Y, FENG XJ, et al.Effects of Pachymic Acid on Proliferation, Apoptosis, Migration, Invasion of Colon Cancer Cells, and the Expression of PERK/ATF4 Signaling Pathway Proteins[J]. Shandong Medical Journal(山东医药), 2023, 63(6): 38-42.
[19] SUN GX, ZHANG DL, CAO QX, et al.Pachymic Acid Regulates the NF-κB Pathway to Induce Apoptosis and Cell Cycle Arrest in Cervical Cancer Cells[J]. Journal of Chinese Medicinal Materials(中药材), 2023(12): 3109-3113.
[20] LIAO WR.Pachymic Acid Inhibits Hepatocellular Carcinoma through Upregulation of ANKRD1: Mechanism and Research[D]. Kunming: Kunming Medical University, 2023.
[21] LI R, TAN XD, HU YY.Pachymic Acid Inhibits Migration, Invasion, and Epithelial-Mesenchymal Transition in Human Pancreatic Cancer PANC-1 Cells[J]. Journal of Jilin University (Medical Edition)(吉林大学学报医学), 2023, 49(2): 315-323.
[22] DONG J, ZHAO JF, ZHANG LC, et al.Pachymic Acid Affects the Biological Characteristics of Renal Cancer Cells via the Wnt Signaling Pathway[J]. Chinese Journal of Gerontology(中国老年学杂志), 2019, 39(9): 2241-2244.
[23] LUO YY, FENG XY, CHU ZW, et al.Pachymic Acid Inhibits the Invasion and Metastasis of Renal Cancer Cells via Regulation of MMP/TIMP Balance through Smads[J]. Chinese Journal of Experimental Formulae(中国实验方剂学杂志), 2023, 29(7): 76-83.
[24] WANG W, XU CG, ZHOU XJ, et al.Research on the in vitro Cytotoxic Effect of Poria Cocos Acid on Bladder Cancer Cell Line BIU87[J]. International Journal of Urology(国际泌尿系统杂志), 2015, 35(5): 4.
[25] MA J, LIU J, LU C, et al.Pachymic Acid Induces Apoptosis via Activating ROS-Dependent JNK and ER Stress Pathways in Lung Cancer Cells[J]. Cancer Cell Int, 2015, 15: 78.
[26] LU C, CAI D, MA J.Pachymic Acid Sensitizes Gastric Cancer Cells to Radiation Therapy by Upregulating Bax through Hypoxia[J]. Am J Chin Med, 2018, 46(4): 875-890.
[27] SANG J, LI L, JIANG J, et al.Mechanistic Study of the Effects of Pachymic Acid on Myocardial Ischemia-Reperfusion Injury in Rats[J]. Journal of Regional Anatomy and Surgical Science(局解手术学杂志), 2023, 32(10): 859-864.
[28] FENG LL, CAO H, LI H.Pachymic Acid Alleviates Myocardial Fibrosis in Rats with Acute Myocardial Infarction by Regulating the JAK2/STAT3/SOCS3 Signaling Pathway[J]. Journal of Labelled Immunoassays & Clinical(标记免疫分析与临床), 2023, 30(9): 1539-1545.
[29] WANG FF, CHEN BY, LI Q.Pachymic Acid Inhibits Oxidative Glucose Deprivation/Reoxygenation-Induced Ferroptosis in Myocardial Cells by Regulating the Nrf2/SLC7A11/GPX4 Signaling Pathway[J]. Journal of Chinese and Western Medicine for Cardiovascular Diseases(中西医结合心脑血管病杂志), 2024, 22(2): 267-273.
[30] PANG Y, ZHU S, PEI H.Pachymic Acid Protects against Cerebral Ischemia/Reperfusion Injury by the PI3K/Akt Signaling Pathway[J]. Metab Brain Dis, 2020, 35(4): b673-680.
[31] HUANG PF.Study on the Mechanism of Pachymic Acid Regulating the PI3K/Akt/FoxO1 Pathway to Alleviate Oxygen-Glucose Deprivation/Reoxygenation Injury in Brain Microvascular Endothelial Cells[D]. Tianjin: Tianjin University of Traditional Chinese Medicine, 2021.
[32] GUI Y, SUN L, LIU R, et al.Pachymic Acid Inhibits Inflammation and Cell Apoptosis in Lipopolysaccharide (LPS)-Induced Rat Model with Pneumonia by Regulating NF-κB and MAPK Pathways[J]. Allergol Immunopathol (Madr), 2021, 49(5): 87-93.
[33] WANG YM, GAN DK, ZHAO RY, et al.Effects of Pachymic Acid on Airway Inflammation in Asthmatic Rats by Regulating the Lyn/Syk Signaling Pathway[J]. Journal of Immunology(免疫学杂志), 2023, 39(9): 790-796.
[34] YANG Y, CHEN F, FENG RX, et al.Mechanism of Protective Effects of Pachymic Acid on Acute Radiation-Induced Lung Injury in Mice[J]. Journal of Plateau Medicine and Biology(中国高原医学与生物学杂志), 2022, 43(4): 268-274.
[35] ZHANG SW, CHENG SL, XING QF.Pachymic Acid Alleviates Damage to Colonic Epithelial Cells in Ulcerative Colitis Rats by Inhibiting the cGAS-STING Signaling Pathway[J]. Journal of Immunology(免疫学杂志), 2023, 39(8): 672-680.
[36] SHAO RR, YANG Z, ZHANG WJ, et al.Pachymic Acid Alleviates Crohn’s Disease in Mice by Inhibiting the PI3K/AKT Signaling Pathway to Antagonize Intestinal Epithelial Cell Apoptosis[J]. Journal of Southern Medical University(南方医科大学学报), 2023, 43(6): 935-942.
[37] FENG ZH.Study on the Anti-Adenomatous Cystitis Effects of Pachymic Acid and Its Targets Based on Bioinformatics and Experiments[D]. Guilin: Guilin Medical University, 2022.
[38] WU Y, YING J, ZHU X, et al.Pachymic Acid Suppresses the Inflammatory Response of Chondrocytes and Alleviates the Progression of Osteoarthritis via Regulating the Sirtuin 6/NF-κB Signal Axis[J]. Int Immunopharmacol, 2023, 124(Pt A): 110854.
[39] WU Z, CHEN X, NI W, et al.The Inhibition of Mpro, the Primary Protease of COVID-19, by Poria Cocos and Its Active Compounds: a Network Pharmacology and Molecular Docking Study[J]. RSC Adv, 2021, 11(20): 11821-11843.
[40] AKIHISA T, NAKAMURA Y, TOKUDA H, et al.Triterpene Acids from Poria Cocos and Their Anti-Tumor-Promoting Effects[J]. J Nat Prod, 2007, 70(6): 948-953.
[41] YANG Z, DU R, CHANG A, et al.The in vitro Anti-Biofilm Activity of the Etoac Extract of Poria Cocos against Escherichia Coli[J]. Asian J Pharma Res Deve, 2013, 1: 152-156.
[42] HUANG YC, CHANG WL, HUANG SF, et al.Pachymic Acid Stimulates Glucose Uptake through Enhanced GLUT4 Expression and Translocation[J]. Eur J Pharmacol, 2010, 648(1-3): 39-49.
[43] CHEN B, ZHANG J, HAN J, et al.Lanostane Triterpenoids with Glucose-Uptake-Stimulatory Activity from Peels of the Cultivated Edible Mushroom Wolfiporia Cocos[J]. J Agric Food Chem, 2019, 67(26): 7348-7364.
[44] LI TH, HOU CC, CHANG CL, et al.Anti-Hyperglycemic Properties of Crude Extract and Triterpenes from Poria Cocos[J]. Evid Based Complement Alternat Med, 2011, 2011: 128402.
[45] TAN YJ, SHI XY, JIA ZX, et al.Analysis of Professor Lin Xianming’s Medication Patterns for Treating Insomnia Based on Data Mining[J]. China Journal of Traditional Chinese Medicine and Pharmacy(中国中医药科技), 2023, 30(3): 478-481.
[46] HUANG XW, WANG Y, WANG YJ, et al.Study on the Effects of Jujube Seed, Poria, and Polygonatum Cautious Syrup on Insomnia of Yin Deficiency Type[J]. Ginseng Research(人参研究), 2022, 34(2): 21-26.
[47] WU Y, CUI YX, ZHANG ZH. Exploration of the Formulation Principles for Treating Insomnia in“Newly Compiled National Chinese Patent Medicine”Based on Data Mining[J]. Practical Journal of Chinese Internal Medicine(实用中医内科杂志), 2023, 37(5): 31-33, 149-150.
[48] SHAH VK, NA SS, CHONG MS, et al.Poria cocos Ethanol Extract and Its Active Constituent, Pachymic Acid, Modulate Sleep Architectures via Activation of GABAA-Ergic Transmission in Rats[J]. J Biomed Res, 2015, 16: 84-92.