中国药物警戒 ›› 2024, Vol. 21 ›› Issue (2): 235-240.
DOI: 10.19803/j.1672-8629.20230494

• 综述 • 上一篇    

重楼抗肿瘤活性成分分类及作用机制研究进展

辛灵怡1,2, 杨洋3, 朱婧1,2, 何娜1,2, 张静媚1,2, 王航天1,2, 陈琴华3, 杨光义1,2,*   

  1. 1深圳市中西医结合医院药剂科,广东 深圳 518000;
    2广州中医药大学第七临床医学院,广东 深圳 518000;
    3深圳市宝安纯中医治疗医院药学部,广东 深圳 518102
  • 收稿日期:2023-08-16 出版日期:2024-02-15 发布日期:2024-02-06
  • 通讯作者: *杨光义,男,博士,教授,中药质量分析及药理药效研究。E-mail:13971908298@163.com
  • 作者简介:辛灵怡,女,在读硕士,中药质量分析及作用机制研究。
  • 基金资助:
    广东省中医药局项目(20221340); 深圳市科技创新委员会基础研究面上项目(JCYJ20210324142012033); 深圳市‘医疗卫生三名工程’项目资助(SZZYSM202106004)

Classification of anti-tumor active ingredients of Paridis Rhizoma and research progress in mechanisms of action

XIN Lingyi1,2, YANG Yang3, ZHU Jing1,2, HE Na1,2, ZHANG Jingmei1,2, WANG Hangtian1,2, CHEN Qinhua3, YANG Guangyi1,2,*   

  1. 1Department of Pharmacy, Shenzhen Hospital of Integrated Traditional Chinese and Western Medicine, Shenzhen Guangdong 518000, China;
    2Key Laboratory of TCM Clinical Pharmacy, Shenzhen Bao’an Authentic TCM Therapy Hospital, Shenzhen Guangdong 518000, China;
    3Department of Pharmacy, Shenzhen Bao’an Chinese Medicine Hospital, Guangzhou University of Chinese Medicine, Shenzhen Guangdong 518102, China;
  • Received:2023-08-16 Online:2024-02-15 Published:2024-02-06

摘要: 重楼是清热解毒传统中药。重楼皂苷是重楼最主要的抗肿瘤活性成分,包括50多种化合物,其中具有抗肿瘤作用的成分为重楼皂苷I、II、II、VII等,对于治疗多种癌症效果显著,如肝癌、结肠癌、脑瘤、大肠癌、食管癌、肺癌、鼻咽癌等。这些成分主要是异螺甾烷醇型甾体皂苷类成分,以重楼皂苷I含量最多,其次有重楼皂苷II、薯蓣皂苷、重楼皂苷A 、纤细薯蓣皂苷、重楼皂苷VI、重楼皂苷VII、重楼皂苷H、重楼皂苷E等。近年来,重楼皂苷抗肿瘤作用逐渐被发现并应用到临床中,但重楼皂苷不良反应也有报道,如重楼皂苷I对肝脏的毒性损伤等。本文对重楼中的皂苷类成分进行分类并综述异螺甾烷醇型皂苷抗肿瘤作用机制的最新研究进展,以总结重楼皂苷抗肿瘤作用的活性成分及作用机制,为进一步研究重楼皂苷抗肿瘤作用及安全用药提供参考。

关键词: 重楼, 重楼皂苷, 抗肿瘤, 异螺甾烷醇型, 活性成分, 作用机制

Abstract: Paridis Rhizoma is a traditional Chinese medicine for clearing away heat and toxic materials. Polyphyllin, as the most important anti-tumor active ingredient of Paridis Rhizoma, contains more than 50 types of compounds, among which the ingredients with anti-tumor effects are polyphyllin I, II, VI, VII. It is effective in treating many types of tumor cancers, such as liver cancer, colon cancer, brain tumor, colorectal cancer, esophageal cancer, lung cancer and nasopharyngeal carcinoma. These ingredients are mostly isospirostanol saponins, dominated by polyphyllin I, followed by polyphyllin II, diosgenin, polyphyllin A, gracillin, polyphyllin VI, polyphyllin VII, polyphyllin H and polyphyllin E. In recent years, the anti-tumor effects of polyphyllin have been gradually discovered and applied in clinic, but the adverse effects of Paris saponins have also been reported, such as the toxic damage of polyphyllin I to the liver. In this paper, the saponin components in Paridis Rhizoma are classified while the latest progress in research on the anti-tumor mechanism of isospirostanol saponins is reviewed in order to summarize the active components and mechanism of action of the anti-tumor effect of Paris saponins and to provide reference for studies on anti-tumor effects of polyphyllin and the safety of medication.

Key words: Paridis Rhizoma, polyphyllin, antitumor, isospirostanol, active ingredient, mechanism

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