十六种壮药毒性药材抗肿瘤活性评价及筛选

doi:10.19803/j.1672-8629.20240392

摘要/Abstract

摘要： 目的研究16种壮药毒性药材抗肿瘤活性,为壮药抗肿瘤治疗提供参考。方法基于壮医“毒论”思想,利用国家科技基础资源调查专项收集的壮药毒性药材,采用文献分析法对其中16种药材的肿瘤抑制效果进行梳理,结果表明这些药材对肺癌、乳腺癌、宫颈癌和胃癌等肿瘤均具有抑制作用。在此基础上,采用细胞计数试剂盒（CCK-8）法分析16种壮药毒性药材提取物对肺癌A549细胞、乳腺癌MCF-7细胞、宫颈癌Hela细胞和胃癌BGC823细胞的抑制活性及半数抑制浓度（IC₅₀）。结果八角莲（RHIZOMA DYSOSMATIS）提取物对上述4种肿瘤细胞均具有一定的抑制作用,其对4种肿瘤细胞的IC₅₀分别为0.928 6、0.622 6、0.240 5、1.737 mg·L^-1,且抑制作用优于阳性对照阿霉素。巴豆（CROTONIS FRUCTUS）提取物对上述4种肿瘤细胞具有一定抑制作用,其他14种药材对4种肿瘤细胞无抑制作用。结论为八角莲抗肿瘤功效的开发应用及毒性药材来源抗肿瘤药物研发提供了参考。

关键词: 毒性药材, 提取物, 抗肿瘤, 八角莲, 壮药, 阿霉素

Abstract: Objective To study the anti-tumor activity of 16 toxic herbs of Zhuang medicine in order to provide references for the anti-tumor treatment with Zhuang medicine. Methods Based on the “poison theory” in Zhuang medicine, the tumor inhibitory effects of 16 medicinal materials were analyzed with literature research methods using toxic medicinal materials of Zhuang medicine collected from the national scientific resources investigation project. The results showed that these medicinal materials had inhibitory effects on tumors such as lung cancer, breast cancer, cervical cancer, and gastric cancer. Furthermore, the inhibitory effects and half inhibitory concentration (IC₅₀) of extracts of 16 kinds of toxic medicinal materials of Zhuang medicine on lung cancer A549 cells, breast cancer MCF-7cells, cervical cancer Hela cells and gastric cancer BGC823 cells were analyzed using the CCK-8 method. Results The extracts of RHIZOMA DYSOSMATIS had a significant inhibitory effects on the above four types of tumor cells with IC₅₀values of 0.928 6, 0.622 6, 0.240 5 and 1.737 mg·L^-1, respectively. The inhibitory effects were better than those of the positive control doxorubicin. The extracts of CROTONIS FRUCTUS had some inhibitory effects on the above four types of tumor cells, while the other 14 medicinal herbs had no inhibitory effect. Conclusion This research provide a reference for the development and application of anti-tumor effects of D. versipellis, and also provide a reference for the development of anti-tumor drugs derived from toxic medicinal materials.

Key words: Toxic Medicinal Materials, Extract, Antitumor, RHIZOMA DYSOSMATIS, Zhuang Medicine, Doxorubicin

中图分类号:

R994.11
R285

宋中旭, 胡娇娇, 金艳, 赵玉洋, 田慧, 袁媛. 十六种壮药毒性药材抗肿瘤活性评价及筛选[J]. 中国药物警戒, 2025, 22(5): 539-546.

SONG Zhongxu, HU Jiaojiao, JIN Yan, ZHAO Yuyang, TIAN Hui, YUAN Yuan. Evaluation and Selection of Antitumor Activity of Sixteen Zhuang Toxic Medicinal Materials[J]. Chinese Journal of Pharmacovigilance, 2025, 22(5): 539-546.

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https://zgywjj.magtechjournal.com/CN/Y2025/V22/I5/539

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