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20 August 2018, Volume 15 Issue 8 Previous Issue    Next Issue

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Study on Toxicity of Gynura Divaricata Aqueous Extract by Gavage for 30 Days in Rats YUE Tun, MOU Huaming, LI Jing, SHU Chaolin, WANG Lei 2018, 15(8): 449-451.  Abstract ( 505 )   PDF (736KB) ( 580 )   Objective To investigate the safety of Gynura divaricata aqueous extract, and to provide toxicological basis for its application. Methods 80 rats were randomly divided into 4 groups, each group was given distilled water and Gynura divaricata aqueous extract intragastrically in dose of 20, 10, 4 g·kg-1 for 30 days. Parameters examined included general condition, body weight, organ coefficient, blood cell, blood biochemistry, and histopathological examination. Results The mental state, behavioral activities, weights, blood cell, blood biochemistry, organ coefficient in rats had no significant difference by comparing with control group. The histopathological examination of heart, liver, spleen, stomach, kidney, testis, ect did not discover singificant pathological changes related to drug toxicity. Conclusion The 30 days feeding test of Gynura divaricata aqueous extract has no siginficant toxicity to rats. References | Related Articles | Metrics

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Effects and Safety of Small Doses Dopamine Hydrochloride Combined with High Frequency Oscillatory Ventilation in Newborns with Persistent Pulmonary Hypertension ZHANG Yuxian, LIN Jing, QI Xuehao 2018, 15(8): 452-455.  Abstract ( 356 )   PDF (740KB) ( 152 )   Objective To study the application effects and the safety of small doses dopamine hydrochloride combined with high frequency oscillatory ventilation in the treatment of persistent pulmonary hypertension of newborn (PPHN). Methods The 68 patients of PPHN selected from April 2014 to August 2016 from Shanxi Provincial Peoples' Hospital were randomly divided into study group and control group, 34 cases of each group. The control group was given conventional treatment of sedation, anti-infection, high frequency oscillatory ventilation and so on. The study group was given small doses dopamine hydrochloride intravenous infusion therapy on the basis of conventional treatment. Clinical effects were evaluated by comparing arterial blood gas index, laboratory index, PASP, BNP, EPO index, ventilator use time, clinical efficacy and adverse reaction. Results After treatment, arterial blood gas index, laboratory index, PASP, BNP, EPO levels of study group were significantly better than control group (P<0.05). The ventilator used time of study group was significantly less than control group (P <0.05). The total effective rate was 97.06% in the study group, and 82.35% in the control group (P<0.05). There were no serious adverse events in both groups during treatment. Conclusion Small doses dopamine hydrochloride combined with high frequency oscillatory ventilation in the treatment of persistent pulmonary hypertension of newborn have significant effects, which can significantly improve the patient's blood gas index and high blood pressure signs, regulate the level of hypoxia inducible factor with higher safety. References | Related Articles | Metrics

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Joint Effects of Shear Stress and Pressure on Secretion of PAI-1,t-PA and vWF in Endothelial Cells of Isolated Arterial Vessels in Rabbits YIN Xiaojie, CAO Jun, HAO Yangyang, GONG Leilei, WANG Lan, WANG Wei, LIANG Rixin, LIAO Fulong 2018, 15(8): 456-461.  Abstract ( 365 )   PDF (1354KB) ( 148 )   Objective To study the joint effects of shear stress and pressure on secretion and expression of PAI-1,t-PA, vWF in endothelium of isolated rabbit vessel. Methods Ex vivo arterial perfusion system was used to establish the rabbit artery perfusion model under different flow conditions of shear stress (2~22 dyn·cm-2) and different pressure(9.0~48.4 mmHg). The perfusate was collected to determine the level of vWF, PAI-1 and t-PA by using radioimmunoassay. And the expression level of vWF mRNA,PAI-1 mRNA and t-PA mRNA was measured by real-time PCR method. Results The low shear stress combined with the low normal pressure, the medium shear stress combined the medium normal pressure and the higher shear stress with the higher normal pressure decreased the level of PAI-1 in perfusate, and meanwhile up-regulated the gene expression of PAI-1. The medium shear stress combined the medium normal pressure increased the level of t-PA in perfusate and up-regulated expression of t-PA. The high shear stress combined with the high normal pressure decreased the level of vWF. Conclusion In isolated blood vessel model loaded by shear stress, shear stress and pressure could exert a joint effects on endothelial functions, which may be related with gene expression of vWF, PAI-1 and t-PA, which indicated that the physical and pathological importance deserves further investigation on the quantitative relationship between biological effects and shear stress. References | Related Articles | Metrics

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Study on the Antithrombotic Mechanism of Joint of Shear Stress with the Fruit of Crataegus Pinnatifida Bge. Var. majar N.E. Br. and the Root of Salviae Miltiorrhizae Bge WANG Wei, GONG Leilei, LI Li, WANG Lan, YIN Xiaojie, LIANG Rixin, LIAO Fulong 2018, 15(8): 462-466.  Abstract ( 402 )   PDF (1043KB) ( 147 )   Objective To investigate the joint effects of flow shear stress and blood-activiating and stasis-dissolving drugs the fruit of Crataegus Pinnatifida Bge. Var. majar N.E. Br.(CP) and the root of Salviae Miltiorrhizae Bge(SM) on the expression of PAI-1, t-PA and ICAM-1 in endothelial cells damaged by OX-LDL and its possible antithrombotic mechanisms. Methods By using Bioflux 1000 microfluidic system, shear stresses of 0.1 Pa and 0.9 Pa were applied together with different doses of the fruit of CP and the root of SM treatment on human vascular endothelial cells (HUVECs) damaged by OX-LDL, then the cell supernatant was collected to detect concentration of PAI-1,t-PA and ICAM-1 by ELISA, the mRNA expressions of PAI-1,t-PA and ICAM-1 in cells were detected by RT-PCR. Results Compared with the model group, the contents of PAI-1 mRNA expressions were lower after treated with the fruit of CP and the root of SM and reduced the secretion of PAI-1 in cells supernatant. Physical shear stress of 0.9 Pa combined with the fruit of CP and the root of SM could significantly promote the endothelial secretion of t-PA and the contents of t-PA mRNA expressions were increased. The contents of ICAM-1 expressions were lower after treated with the fruit of CP and the root of SM in low shear stress condition. Conclusion The fruit of CP and the root of SM can inhibit thrombosis by inhibiting the expression of PAI-1 in endothelial cells. Physical shear stress and the fruit of CP and the root of SM can inhibit thrombosis by regulating the stability of the fibrinolytic system; low shear stress may influence the fruit of CP and the root of SM antithrombotic effect through downregulation of ICAM-1. References | Related Articles | Metrics

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Development of Biomechanopharmacology ZHANG Qian, LIU Lei, YOU Yun, LIAO Fulong 2018, 15(8): 467-469.  Abstract ( 430 )   PDF (537KB) ( 149 )   This paper reveals formation of the borderline discipline of biomechanopharmacology from the multi-targeted biological effects of shear stress. It reviews the recent biomechanopharmacological studies of herbs with activating blood circulation and removing thrombosis effects, together with such studies of compounds with anti-platelets aggregation effects. We are looking forward to screening Chinese herbs through mechanical ion channel activator or inhibitor by means of biomechanopharmacology. References | Related Articles | Metrics

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Literature Study on Adverse Drug Reactions and Analysis of Risk Factors of Polygonum multiflorum Thunb. and its Common Preparations YU Hongli, YU Dongmei, SONG Haibo, REN Jingtian 2018, 15(8): 470-475.  Abstract ( 512 )   PDF (871KB) ( 222 )   Objective To investigate the general characteristics of adverse drug reaction (ADR) induced by Polygonum multiflorum Thunb. and its common preparations, and analyze their risk factors, so as to provide reference for rational drug use in clinic. Methods The cases of ADR reduced by Polygonum multiflorum Thunb. and its common preparations were retrieved, to analyze the characteristics of ADRs and risk factors. Results In 69 cases included, most of ADR occurred in ten days to one month after treatment. The mainly involved system-organ was hepatobiliary disorders, followed by gastrointestinal disorders. The main clinical manifestations were icteric sclera and skin coloring yellow, ALT and AST increased, TBiL and DBiL increased, urinary coloring yellow, etc. Most patients could recover better after drug withdrawal or symptomatic treatment. Conclusion The mainly involved system-organ was hepatobiliary disorders and gastrointestinal disorders. And the clinical outcomes of patients were better. However, further research is still needed, while strengthening regulation to ensure the rational drug use. References | Related Articles | Metrics

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Literature Analysis of 302 Cases of Musuler System Disorders Induced by Statins GAO Qianqiu, ZHANG Haojia 2018, 15(8): 476-480.  Abstract ( 510 )   PDF (737KB) ( 226 )   Objective To provide references for rational medication through analyzing the characteristics of statin-induced muscular system disorders. Methods "Statin" and "myopathy" were used as keywords to search articles in CNKI database, then they were analyzed according to inclusion and exclusion criteria. Results A total of 34 articles were included, involving 302 cases. Simvastatin was the most common drug reported with myopathy. Eight kinds of drug-drug interaction were found. Conclusion It is important to choose proper statin and monitor drug interaction. More attention should be paid to treatment and prophylaxis of statin-induced muscular system disorders. References | Related Articles | Metrics

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Analysis of 969 Cases of Adverse Drug Reactions Caused by Meglumine Adenosine Cyclophosphate Injection LIU Saiyue, HU Tingxia 2018, 15(8): 481-484.  Abstract ( 427 )   PDF (806KB) ( 928 )   Objective To investigate the occurrence and characteristics of adverse drug reactions(ADRs) caused by meglumine adenosine cyclophosphate injection, so as to provide reference for rational drug use in the clinic. Methods The retrospective study method was used to analyze 969 cases of ADRs caused by meglumine adenosine cyclophosphate injection. These ADRs were collected by Zhejiang ADRs monitoring system from Jan.2010 to Feb.2017.The analysis includes the type of reports, quantity trends, the case of gender, age, medication situation and adverse drug reactions. Results 54% cases were new ADR reports. ADRs caused by meglumine adenosine cyclophosphate injection mostly occurred in the patients aged above 45 years old(85.45%). The SOCs mostly involved in ADRs were systemic reaction, the digestive system, skin and its accessories. The serious ADRs involving SOCs were mainly systemic reaction, skin and its accessories, and respiratory system. Conclusion More attention should be paid to ADRs caused by meglumine adenosine cyclophosphate injection in clinic, especially the serious adverse reactions such as allergic shock. Drug manufacturers should promptly improve the safety information of drug instructions．The rational drug use should be strengthened to improve the safety of drug use in patients. References | Related Articles | Metrics

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Effects of Out-hospital Extended Pharmaceutical Intervention in Myocardial Infarction Patients after PCI on Prognosis and Medication Compliance WANG Minglei, WANG Fang 2018, 15(8): 485-488.  Abstract ( 333 )   PDF (645KB) ( 168 )   Objective To investigate the effects of out-hospital extended pharmaceutical intervention on medication compliance and prognosis of myocardial infarction patients after PCI. Methods 160 myocardial infarction patients after percutaneous coronary intervention (PCI) treated in our hospital during Mar 2014 to May 2017 were selected and divided into control group (with 80 patients) and test group (with 80 patients under out-hospital extended pharmaceutical intervention). Prognosis and medication compliance after 1 year discharge between the two groups were compared. Results General data of the two groups had no significant differences between the two groups(P >0.05). LVEDV of control group was higher than test group, LVEF and E/A of control group was lower than test group and the differences were significant (P <0.05). The drug compliance of the test group was higher than that of the control group, the number of compliance was significantly higher than that of the control group, and the number of partial compliance was lower than that of the control group (P <0.05). On the part of prognosis, more patients of control group had cardiovascular adverse events than test group. Among these events, incidences of control group of revascularization and heart failure were significantly higher than test group, which was significantly higher than control group (P<0.05). Conclusion Out-hospital extended pharmaceutical intervention can improve medication compliance and reduce the incidence of cardiac events of myocardial infarction patients after PCI. References | Related Articles | Metrics

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Retrospective Analysis of 125 Cases of Adverse Drug Reactions Induced by Tigecycline CUI Hongxia, YU Suwen 2018, 15(8): 489-492.  Abstract ( 394 )   PDF (704KB) ( 505 )   Objective To pay more attention to the adverse drug reactions induced by tigecycline and provide references for rational use of drugs. Methods Patients receiving tigecycline in a level 3 general hospital during 2012-2018 were analyzed retrospectively to observe the change of symptom, sign and lab indexes after using tigecycline injection. 125 cases of adverse reactions were extracted, and the case information was summarized and analyzed. Results The main diseases of 125 patients were lung infection or skin and soft tissue, abdominal cavity and urinary system infection. 125 cases of ADR include 51 cases of inducing or aggravating blood coagulation abnormality(41.8％), 39 cases of liver function injury(31.2％), 19 cases of vomiting and other gastrointestinal discomfort(15.2％),16 case of rash and pruritus(12.8％). ADRs of digestive system were mild and recovered after symptomatic treatment as inhibiting acid, antiemetic. Severe ADR as liver function injury could not be recovered after symptomatic treatment as protecting liver, reducing enzyme. Coagulation function disorder was aggravated after medication, which mainly manifested as the prolongation of TT and the elevation of INR, D-dimer, PT, etc. After plasma infusion treatment, 31 cases improved, 17 cases did not improve, and 3 cases died. Conclusion Great importance should be attached to severe ADR as coagulation function disorder, liver function injury when using tigecycline, in order to ensure the safety of drug use. References | Related Articles | Metrics

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Progress of Pharmacology, Potential Hepatotoxicity and Pharmacokinetics of Dioscin LUO Pan, LV Chunming, ZHOU Wenbin, KOU Fang, WEI Hai 2018, 15(8): 493-498.  Abstract ( 474 )   PDF (887KB) ( 667 )   Dioscin is an iso-spirostanol derivative. It is the major effective component for the quality control of many herbal medicines, Chinese patent medicines and herbal medicine prescriptions. This paper reviewed the researches on the pharmacology, hepatotoxicity and pharmacokinetics of dioscin in recent years. Dioscin has many pharmacological effects, especially in the cardiovascular regulation. However, the potential hepatotoxicity of dioscin should be paid more attention. Its poor absorption, slow metabolism and low bioavailability should also be noticed. The dose-dependent hepatotoxicity of dioscin should be taken into account for the safety of the prescriptions containing dioscin in clinic. References | Related Articles | Metrics

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One Case of Mental Abnormality Induced by Drug Interaction WANG Ying, CUI Xiangli, LIU Lihong 2018, 15(8): 499-500.  Abstract ( 495 )   PDF (528KB) ( 491 )   References | Related Articles | Metrics

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One Case of Severe Anaphylaxis Shock Induced by Tranexamic Acid Injection WANG Yiting, LI Weiwei, XIE Jingwen, GAO Min, LI Xiaoyan 2018, 15(8): 501-502.  Abstract ( 465 )   PDF (532KB) ( 190 )   References | Related Articles | Metrics

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One Case of Hypotensive Shock Induced by Inhaling Atomized Salbutamol Sulfate Solution YANG Anpei, XIE Yanbing 2018, 15(8): 503-503.  Abstract ( 369 )   PDF (520KB) ( 130 )   References | Related Articles | Metrics

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One Case of Anaphylactic Shock Induced by Gonadorelin for Injection JIANG Yongxian, LI Gen, WANG Han, WANG Yulan 2018, 15(8): 504-505.  Abstract ( 340 )   PDF (534KB) ( 133 )   References | Related Articles | Metrics