Abstract: Objective To study the application effects and the safety of small doses dopamine hydrochloride combined with high frequency oscillatory ventilation in the treatment of persistent pulmonary hypertension of newborn (PPHN). Methods The 68 patients of PPHN selected from April 2014 to August 2016 from Shanxi Provincial Peoples' Hospital were randomly divided into study group and control group, 34 cases of each group. The control group was given conventional treatment of sedation, anti-infection, high frequency oscillatory ventilation and so on. The study group was given small doses dopamine hydrochloride intravenous infusion therapy on the basis of conventional treatment. Clinical effects were evaluated by comparing arterial blood gas index, laboratory index, PASP, BNP, EPO index, ventilator use time, clinical efficacy and adverse reaction. Results After treatment, arterial blood gas index, laboratory index, PASP, BNP, EPO levels of study group were significantly better than control group (P<0.05). The ventilator used time of study group was significantly less than control group (P <0.05). The total effective rate was 97.06% in the study group, and 82.35% in the control group (P<0.05). There were no serious adverse events in both groups during treatment. Conclusion Small doses dopamine hydrochloride combined with high frequency oscillatory ventilation in the treatment of persistent pulmonary hypertension of newborn have significant effects, which can significantly improve the patient's blood gas index and high blood pressure signs, regulate the level of hypoxia inducible factor with higher safety.

Key words: dopamine hydrochloride, newborn, persistent pulmonary hypertension, arterial blood gas index, high frequency oscillatory ventilation