Abstract: Objective To pay more attention to the adverse drug reactions induced by tigecycline and provide references for rational use of drugs. Methods Patients receiving tigecycline in a level 3 general hospital during 2012-2018 were analyzed retrospectively to observe the change of symptom, sign and lab indexes after using tigecycline injection. 125 cases of adverse reactions were extracted, and the case information was summarized and analyzed. Results The main diseases of 125 patients were lung infection or skin and soft tissue, abdominal cavity and urinary system infection. 125 cases of ADR include 51 cases of inducing or aggravating blood coagulation abnormality(41.8％), 39 cases of liver function injury(31.2％), 19 cases of vomiting and other gastrointestinal discomfort(15.2％),16 case of rash and pruritus(12.8％). ADRs of digestive system were mild and recovered after symptomatic treatment as inhibiting acid, antiemetic. Severe ADR as liver function injury could not be recovered after symptomatic treatment as protecting liver, reducing enzyme. Coagulation function disorder was aggravated after medication, which mainly manifested as the prolongation of TT and the elevation of INR, D-dimer, PT, etc. After plasma infusion treatment, 31 cases improved, 17 cases did not improve, and 3 cases died. Conclusion Great importance should be attached to severe ADR as coagulation function disorder, liver function injury when using tigecycline, in order to ensure the safety of drug use.

Key words: tigecycline, adverse drug reaction, retrospective analysis