Literature Analysis of 53 Reports of Drug-induced Interstitial Pneumonia

Abstract

Abstract: ObjectiveTo study the drugs leading to interstitial pneumonia and analyze their clinical characteristics. MethodsWe searched the literatures from 1994 to 2013 by key words of "interstitial pneumonia" in China Digital Library, China National Knowledge Infrastructure, Wanfang Database, and summarized them. ResultsA total of 74 relevant articles were identified, which reported 53 cases of drug-induced interstitial neumonia, involving 15 kinds of drugs. The drugs included gefitinib(15), rituximab(9), leflunomide(8), amiodarone(8), erlotinib(5), interferon(2), 5-fluorouracil(1), granulocyte colony-stimulating factor(1), gemcitabine(1), carmustine(1), measles vaccine(1), paraquat(1), et al.The result showed that 53 cases contained 17 cases(33.33%) cured, 19 cases(37.26%) improved , 15 cases(29.41%) died and 2 cases unclear. ConclusionThe clinical manifestations of interstitial pneumonia induced by drugs were similar, but the pathogenesis was unknown. The drugs leading to higher incidence were gefitinib, rituximab,leflunomide, amiodarone and erlotinib.

Key words: drug, interstitial pneumonia, adverse reaction

CLC Number:

R994.11

HU Mei-hui, SUN An-xiu. Literature Analysis of 53 Reports of Drug-induced Interstitial Pneumonia[J]. Chinese Journal of Pharmacovigilance, 2014, 11(6): 347-350.

References

[1] 张闽光,王建萍,殷晓聆,等.吉非替尼所致致死性间质性肺病变临床和CT表现[J].中国中西医结合影像学杂志,2008,6(4):241-243.
[2] 杨晓辉,彭焱.吉非替尼相关间质性肺炎致死亡[J].药物不良反应杂志,2012,14(2):118-120.
[3] 冯仲珉,曹阳, 孙利敏, 等.吉非替尼治疗非小细胞肺癌指骨转移引起间质性肺炎1例[J].大连医科大学学报,2008,30(6):591-592.
[4] 张婧,贺江虹.吉非替尼治疗晚期肺腺癌致间质性肺炎1例[J].实用医学杂志,2012,28(2):326.
[5] 粟毅,彭丽,吴亚梅. 吉非替尼维持治疗非小细胞肺癌致间质性肺炎1例[J]. 重庆医学,2011,40(3):310.
[6] 赵农,黄捷晖,张艳.吉非替尼致间质性肺炎1例[J].临床肺科杂志,2008,13(9):1215.
[7] 崔慧娟,黄琼, 陈豫.吉非替尼致间质性肺炎1例[J].临床肿瘤学杂志,2007,12(3):235-236.
[8] 梁洪享,黄燕,丁罡,等.吉非替尼致间质性肺炎1例[J].实用医学杂志,2009,25(1):162.
[9] 周燕,戴吉,祝永忠,等.吉非替尼致间质性肺炎CT 影像分析[J].医学影像,2010,48(12):61-62.
[10] 吴志勇,张肖,孙胜杰,等.吉非替尼致间质性肺炎并囊样薄壁空洞形成一例[J].中国临床药理学与治疗学,2012,17(3):280-281.
[11] 罗长琴,王丽娜,李雨遥,等.吉非替尼致间质性肺炎并文献回顾[J].现代肿瘤医学,2012,20(9):1858-1862.
[12] 王晖,管湘萍,苑东明.吉非替尼治疗非小细胞肺癌致间质性肺炎1例[J].中国实用医药,2013,8(6):186-187.
[13] 王伟兰,孙艳.口服吉非替尼同步放疗致间质性肺炎 1例[J].药学与临床研究,2008,16（6):506-507.
[14] 曹淑芳,邓青南,张德明.表皮生长因子受体抑制剂IRESSA致间质性肺炎1例[J].广东药学院学报,2004,20（3):304-305.
[15] 华怡.利妥昔单抗治疗淋巴瘤并发间质性肺炎的观察与护理[J].上海护理,2011, 11(5):52-53.
[16] 段争,杨红申,张聪敏.来氟米特致急性间质性肺炎1例[J]. 解放军医学杂志,2009,34(8):1029.
[17] 蔡叔宁,牟丽.来氟米特致间质性肺炎及药物性肝炎一例[J].中国药物与临床,2007,7（7):504.
[18] 陈琳,张恩娟,张喆 ,等.来氟米特致间质性肺炎继发死亡1例[J].药事管理,2009,6（4):250.
[19] 朴雪梅,张赞玲.来氟米特致肺间质病变一例病历分析[J].医学信息,2010,11:3188.
[20] 王华,张书锋.来氟米特致呼吸系统不良反应2例[J].实用儿科临床杂志,2007,22（17):1298.
[21] 熊祖军,向勇,彭士芳.1例口服来氟米特致急性间质性肺炎的观察及护理[J].护理实践与研究,2009,16（6):127-128.
[22] 黄志文,李琦,吴学玲,等.来氟米特致急性间质性肺炎一例[J].中国呼吸与危重监护杂志,2009,8（1):83-84.
[23] 李彤,付林泉,吴国库.“胺碘酮”致间质性肺炎并多发结核空洞呼衰治愈1例[J].临床肺科杂志,2007,12（1):100.
[24] 任晓蕾,贺真,李玉珍.胺碘酮长期应用致间质性肺炎[J].药物不良反应杂志,2011,13(3):182-183.
[25] 赵翠萍,曲秀芳,黄永麟.胺碘酮致间质性肺炎的探讨[J].中国心血管杂志,1999,4（2):127.