Abstract: Objective To explore the diet factor of adverse drug reactions. Methods The domestic and foreign diet-related adverse drug reactions reported in the literature were collected, and the mechanism was analyzed. Results Diet can affect drug physicochemical properties and pharmacokinetic properties. The synergistic or antagonistic interactions between diet and drug may affect the efficacy and toxicity of drugs. The diet-related adverse drug reactions may be associated with certain nutrient or multiple nutrients in the diet. Conclusion In order to provide data to support the clinical safety of medication, the research of diet factor of adverse drug reactions should be strengthened, and the impact of diet on drug efficacy and safety should be analyzed and summarized.

Key words: adverse drug reactions, diet, interaction