Abstract: Objective To investigate the characteristics of distribution of adverse drug reaction induced by first-line antituberculosis drugs and to provide reference for clinical safety and proper administration. Methods The literature between January 1989 and December 2009 was retrieved. For four first-line drugs(isoniazid, rifampin, ethambutol, pyrazinamide), the time of occurrence of adverse reactions, age and gender distribution of cases and systems or system-organs related adverse reactions caused by individual drug were counted up, the characteristics and factors involved in individual adverse reactions were also analyzed. Results The total of 739 cases were collected, 437 in male, 299 in female, and 3 cases with unknown sex. Ages ranged from 3 months to 82 years old. The shortest time of occurrence of adverse reaction was 2 min and the longest about 50 years. The adverse reactions of antituberculosis drugs were widely distributed in 12 systems, such as the nervous system, urinary system, and hematological system and so on. Multiple adverse reactions included acute renal failure, drug-induced hepatic injury, anaphylactoid purpura, anaphylactic shock, optic neuritis and so on. Conclusion More attention should be paid to the characteristics and rule of distribution of adverse drug reaction of antituberculosis drugs induced in clinical and to ensure safety and proper administration.

Key words: antituberculosis drugs, adverse drug reaction(ADR), literature analysis