Abstract: Objective To analyze the causes of adverse reactions of acute renal failure in a 55-year-old female patient treated with ethambutol hydrochloride, pyrazinamide, rifampicin and isoniazid tablets(Ⅱ), and to summarize the experience and lessons learned at home and abroad. Methods By consulting the related literature and based on the patient's condition, clinical pharmacists identified the possible anti-tuberculosis drug that had induced acute renal failure in the patient. Results The adverse reactions of the patient with acute renal failure might have been due to the intermittent use of rifampicin. Conclusion Prior to treatment with ethambutol hydrochloride, pyrazinamide, rifampicin and isoniazid tablets, the medical history and indications of the patient should be clarified. Medication should be standardized and the intermittent use should be avoided as far as possible The participation of a clinical pharmacist in clinical treatment can help make medication more appropriate and ensure the safety of medication.

Key words: drug-induced acute renal failure, ethambutol hydrochloride, pyrazinamide, rifampicin and isoniazid tablets, rifampin, antituberculosis drugs