Abstract: Objective To explore the characteristics and related factors of adverse drug reactions (ADR) induced by extraction of bone-melon so as to provide references for rational clinical drug use. Methods ADR cases induced by extraction of bone -melon reported in domestic medical journals during 1994～2012 were collected and analyzed statistically. Restuls ADR induced by Extraction of Bone-melon often occurred in aged group. The onset of ADR was usually within 30min after injection. ADR could involve multiple organs and systems, and clinical manifestations were various, mainly allergic reactions. Severe allergic reactions could manifest dyspneic respiration and anaphylactic shock. Conclusion Clinical physicians and pharmacist should pay attention to the ADR induced by extraction of bone-melon and persist in rational drug use.

Key words: extraction of bone-melon, adverse drug reaction, literature, analysis