Abstract: Objective To understand the cases of allergic response caused by insulin, analyze the relevant factors, and providea reference for the clinical use of drugs. Methods 242 cases of insulin-induced allergic reactions were statistically analyzed. Results Male to Female ratio was 1.1:1, 61.1% of the cases involved the elderly, 15.7% of the patients had allergy history, 91.3% of the allergies were due to subcutaneous injection, 50.0% of the patients administered premixed insulin, 80.2% of the cases occurred aftera few or many times administration. The main allergic reactions were local reactions(57.0%), and could be cured or improved mostly. Conclusion Insulin may cause serious allergic reactions and even shock. When we use this drug, we must carefully consider the age, usage, dosage and other relevant factors, then make rational use of drugs to reduce the incidence of allergic reactions.

Key words: insulin, allergic reactions, rational drug use