Abstract: Objective To summarize the regularity and characteristics of adverse drug reaction(ADR) induced by proton pump inhibitors, and provide reference for the rational use of drugs in clinic. Methods Related literatures of ADR induced by proton pump inhibitors were collected from CHKD full-text database during 2008～2012, then the included literatures were statistically analyzed. Results A total of 30 literatures relating to ADR induced by proton pump inhibitors were collected, including 34 cases. This group of ADR induced by proton pump inhibitors involved multiple system -organs , the clinical signs were complex and varied, and symptoms of adverse drug reactions were relatively serious, and rare in clinic, but prognosis was good after stopping drug treatment. Conclusion We should strengthen the understanding of these types of adverse drug reactions, pay attention to the prevention and improve the rational use of proton pump inhibitors.

Key words: proton pump inhibitors, adverse drug reaction, analysis