Abstract: Objective To explore the mechanism through which terazosin tablets induce atrial fibrillation (AF) in order to provide a reference for rational drug use in clinical practice. Methods One case of hypertension complicated with renal artery stenosis treated with terazosin tablets was analyzed based on a literature review. Results A 52-year-old female patient was admitted to the hospital due to dizziness and was diagnosed with cerebral infarction, stage 3 hypertension at extremely high risk, accompanied by atrial septal aneurysm and moderate stenosis of the right renal artery. She was administered 1 mg of terazosin tablets orally before she experienced such symptoms as rapid heartbeat and palpitations. An immediate electrocardiogram showed atrial fibrillation. She was given 47.5 mg of metoprolol sustained-release tablets orally, and her symptoms subsequently subsided. Based on correlation evaluation, it was speculated that the patient's atrial fibrillation might have been caused by terazosin tablets. Conclusion Atrial fibrillation may be one of the potential adverse reactions of terazosin tablets. Therefore, clinicians need to inquire about a patient's history of disease and previous medications, closely monitor the electrocardiogram, and be alert to the risk of recurrence upon re-administration.

Key words: Terazosin, Atrial Fibrillation, Atrial Septal Protrusion Tumor, Renal Artery Stenosis, Adverse Drug Reaction