Retrospective Analysis of 1 229 Cases of Adverse Drug Reactions in Ophthalmology

doi:10.19803/j.1672-8629.2021.04.18

Abstract

Abstract: Objective To analyze how adverse drug reactions (ADR) are caused by ophthalmological drugs in order to provide reference for rational use of drugs and risk prevention. Methods The ADR of 1 299 patients in 228 hospitals of an eye group collected by the drug data reporting platform between May 2017 and May 2020 were retrieved. The top 10 drugs in terms of administration routes, outcomes, main clinical manifestations and the number of ADR cases were evaluated and analyzed. Results Among the 1 229 cases of ADR, 671 (54.6%) were treated with topical drugs, 366 (29.78%) with intravenous drugs, and 152 (12.37%) with oral drugs. Among the top ten types of drugs that caused ADR, intravenous injection of fluorescein sodium injection caused 266 cases (45.70%), and diclofenac sodium eye drops caused 79 cases (13.57%). Sodium fluorescein injection and traditional Chinese medicine injection could cause anaphylactic shock. Conclusion Eye local medication can cause local and systemic adverse reactions. Attention should be paid to the adverse reactions caused by fluorescein sodium injection and traditional Chinese medicine injection, especially severe adverse reactions such as anaphylactic shock.

Key words: pharmaceuticals, adverse drug reaction

CLC Number:

R994.11

HONG Manzhu, DING Lu, HUANG Ying, TANG Xilan. Retrospective Analysis of 1 229 Cases of Adverse Drug Reactions in Ophthalmology[J]. Chinese Journal of Pharmacovigilance, 2021, 18(4): 377-380.

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https://zgywjj.magtechjournal.com/EN/Y2021/V18/I4/377

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