Clinical and Literature Analysis of 107 Cases of Adverse Drug Reactions Induced by Pegaspargase

Abstract

Abstract: Objective To analyze the occurrence and clinical characteristics of adverse drug reactions induced by pegaspargase, so as to provide reference for clinical safe medication. Methods ADR cases induced by pegaspargase in the Institute of Hematology and Blood Disease Hospital, Chinese Academy of Medical Sciences from July 2013 to March 2019 were collected. In addition, case reports of adverse drug reactions induced by pegaspargase were retrieved from the CNKI database, VIP database, Wanfang database and Pubmed database. Then patients information such as gender, age, original disease, medication and the occurrence of adverse reactions was summarized and analyzed. Results Totally 107 patients were retrieved, including 30 clinical cases in our hospital and 77 literature cases. Among them, 67(62.62%) were males and 40(37.38%) were females, and 55(51.40%) were children under 10 years old. Adverse reactions occurred in 3 minutes to 44 days after administration of pegaspargase. The main clinical manifestations were gastrointestinal damage, blood system damage and cardiovascular damage. Conclusion Clinicians and pharmacists should pay attention to the occurrence characteristics of adverse reactions of pegaspargase. When using chemotherapy regimens containing pegaspargase, it should be closely observed the clinical symptoms and monitored related indicators such as coagulation function and liver function, in order to minimize the adverse drug reactions damage caused by pegaspargase.

Key words: pegaspargase, adverse drug reactions, clinical case analysis, literature analysis

CLC Number:

R994.11

MIAO Wenjuan, TIAN Jixin, Yu Yaqing, ZHANG Ping. Clinical and Literature Analysis of 107 Cases of Adverse Drug Reactions Induced by Pegaspargase[J]. Chinese Journal of Pharmacovigilance, 2019, 16(6): 367-373.

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