Abstract: Objective To investigate the general characteristics and relative factor of the adverse drug reactions induced by carboprost methylate, so as to provide reference of clinical rational and safe use of drug. Methods By retrospective study method, we analyzed the 1 189 cases of adverse drug relations/events induced by carboprost methylate in the adverse reaction network platform of Pan-Pearl River Delta from 2005 to 2017. By retrospective study method, we analyzed the patient's age, gender, past history, the purpose of drug use,occurrence time, symptoms of adverse drug reactions, the system involved etc. Results The adverse drug reactions of carboprost methylate mainly occurred on the day of medication. The systems involved of adverse drug reactions include the gastrointestinal system damage, systemic damage,skin and its accessories damage etc.Serious adverse drug reactions mostly occurred in half an hour after the drug use. Conclusion Clinic should pay attention to the drug adverse reactions of carboprost methylate, especially to the serious adverse reactions.Drug manufacturers should promptly revise and improve the safety information of drug instructions,so as to ensure the safety of drug use.

Key words: carboprost methylate, adverse drug reaction, rational use of drug