Analysis of 413 Cases of Adverse Drug Reactions Induced by Fluorescein Sodium Injection

Abstract

Abstract: Objective To investigate the characteristics and mechanisms of adverse drug reactions (ADRs) induced by fluorescein sodium injection, so as to provide technical supports for safe and rational use of drug in clinic.Methods A total of 413 cases of fluorescein sodium injection-caused ADRs were reported in Zhejiang province from January 2010 to June 2017 and analyzed by Excel software.Results The male cases were slightly more than the females. The adverse reactions were in a rapid reactive type. System organ classes(SOCs) mainly involved in adverse reactions were gastrointestinal disorders, accounted for 58.58%, followed by skin and appendages disorders, application site disorders. Serious ADRs mainly involved the general disorders. Allergy test can not completely predict ADRs.Conclusion The adverse reactions caused by fluorescein sodium injection should be paid attention, especially the serious ADRs such as anaphylactic shock and so on. Medical staff should do well in the prevention, monitoring and treatment of ADRs.

Key words: fluorescein sodium injection, adverse drug reaction, reports, monitoring

CLC Number:

R994.11

MA Min-kang ,ZHU Yong,LV Xiao-qin. Analysis of 413 Cases of Adverse Drug Reactions Induced by Fluorescein Sodium Injection[J]. Chinese Journal of Pharmacovigilance, 2018, 15(5): 296-299.

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