Abstract: Objective To investigate the effect of tretinoin tablets in treatment of patients with psoriasis vulgaris on triglycerides.Methods Forty-nine patients with psoriasis vulgaris were enrolled from May 2014 to April 2016 in our hospital and randomly assigned to the control group(n=24) and observation group(n=25). The triglyceride levels of two groups were detected before treatment. The control group received anti-inflammatory or support therapy and the observation group received anti-inflammatory or support therapy plus taking tretinoin tablet 10 mg each time by three times a day. The triglyceride levels of two groups were detected after treatment. The paired t1 test were used for comparison the triglyceride levels before and after treatment, and independent sample t2 test were used for comparison between the triglyceride levels of two groups.Results The average time of therapy of control group was (9.05±1.61) days. The triglyceride levels of control group before and after treatment were (1.09±0.64) mmol·L-1, (1.25±0.47) mmol·L-1 respectively. The difference of them had no statistical significance (t1=0.623,P >0.623). The average time of therapy of observation group was(8.47±1.64) days. The triglyceride levels of observation group before and after treatment were (1.27±0.45) mmol·L-1, (2.39±0.85) mmol·L-1 respectively. The difference of them was statistically significant(t1=5.488, P <0.01). But the difference of the treatment time of two groups was not statistically significant (t2=1.095,P >0.05). The difference of the triglyceride levels of two groups before treatment also had no statistical difference (t2=1.035, P >1.035), but the triglyceride levels of two groups after treatment were statistical significant (t2=5.039, P <0.01).Conclusion Tretinoin tablets in treatment of patients with psoriasis vulgaris could raise the triglyceride levels in a short period of time. Early detecting the blood lipid changes in patients after treatment could effectively reduce the risk of cardiovascular disease in patients.

Key words: tretinoin tablets, psoriasis vulgaris, triglyceride