Research Progress on Small-molecule Compounds  against Connective Tissue Growth Factor

Abstract

Abstract: Objective To provide a concise overview of small molecule connective tissue growth factor (CTGF) inhibitors. Methods A summarization of the small molecules was provided, both the approved drugs and the agents under developing with new structures, that can inhibit CTGF. Results The research on small molecule CTGF inhibitors could be mainly classified into two categories: one is based on the approved drugs or natural products, the other is the small molecule compounds with new structures. Conclusion As a very important cytokine which is only expressed in interstitial cells, CTGF, inducing the fibrosis of TGF-β, is an effective and specific target for anti-fibrosis cytokine in organism. There are only a few structural types of compounds reported, but they will also be the prelude to provide useful references for developing more potential small molecule CTGF inhibitors in the future.

Key words: connective tissue growth factor, tissue fibrosis, small-molecule compound

CLC Number:

R965

LIU Jun-li, ZHANG Mu-xin, LIANG Di, ZHENG Ming-xin, ZHOU Xiao-ping. Research Progress on Small-molecule Compounds against Connective Tissue Growth Factor[J]. Chinese Journal of Pharmacovigilance, 2018, 15(2): 98-102.

References

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Research Progress on Small-molecule Compounds against Connective Tissue Growth Factor

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