Abstract: Objective To investigate the clinical characteristics and occurrence of drug-induced liver injury (DILI), so as to reduce the incidence of adverse drug reactions and promote the rational use of drugs. Methods A retrospective analysis was performed on 106 patients with drug-induced liver injury in our hospital from January 2015 to December 2017. The data were statistically analyzed by SPSS 22.0. The count data expressed as a percentage, measurement data with mean ± standard deviation (ヌ±s), multiple groups were compared using single factor analysis of variance. Results There were 40 males and 66 females with a mean age of (48.12±14.00) years involved. The drugs were orderly ranked traditional Chinese medicine, antineoplastic agents, NSAIDs and anti-infective drugs according to their constituent ratios. The time to onset was within 12 weeks with characteristics of yellow skin, darker urine, decreased appetite, nausea, vomiting and abdominal distension, while 18.4% of patients were asymptomatic. The types of injury were hepatocellular injury (41.51%), mixed type (28.30%) followed by cholestasis type (15.09%) and liver biochemical abnormality (15.09%). The pathological results of 50 patients tended to be drug-induced liver injury.Conclusion Clinical characteristics of drug-induced liver injury were not specific and easy to misdiagnose. However, most of the prognoses were good. Clinicians should strengthen their vigilance against DILI and carry out early identification, timely withdraw suspected drugs and apply appropriate hepatoprotective therapy based on etiology and clinical features.

Key words: drug-induced liver injury, adverse reactions, retrospective analysis