Correlation between Activity of T Lymphocyte Subsets and NK Cells and Antibiotics Use in the Cancer Patients

Abstract

Abstract: Objective To study the correlation between the activity of T lymphocyte subsets, NK cells and antibiotics use in cancer patients. Methods The activity of T lymphocyte subsets and NK cells in the peripheral blood of the cancer patients and healthy controls were detected by using flow cytometry. The correlation between the activity of probiotics and antibiotics use in cancer patients was statistically analyzed by t-test, chi-square test, one-way analysis of variance ( F-test), Student-Newman-Keuls q-test and Pearson correlation analysis. Results Overall comparison: the percentage of CD3⁺, CD4⁺, NK cells, and CD4⁺/CD8⁺ ratio in peripheral blood of the cancer patients were decreased significantly, while the percentage of CD8⁺ was significantly increased, compared with the normal control group. The difference was statistically significant (each P < 0.05). Correlation analysis: there was weakly correlation between the percentage of CD3⁺, CD4⁺, CD8⁺, NK cells, and CD4⁺/CD8⁺ ratio in peripheral blood and the cumulative amount of antibiotics use of the case group ( r= -0.36, -0.40, 0.38, -0.38, -0.36, each P < 0.05). The effects of different factors on expression of T lymphocyte subsets and NK cells in peripheral blood of the healthy controls: the effect of both gender and age on the total number of bacteria and the number of lactobacillus in gastrointestinal tract of the healthy controls dose not reach statistical significance ( P > 0.05). Conclusion There is a weakly correlation between activity of T tymphocyte subsets, NK cells and antibiotics use in cancer patients after antibiotics cumulative use reaches a certain amount in a certain period of time.

Key words: cancer, T lymphocyte subset, NK cell, activity, antibiotic, correlation

CLC Number:

R969.3

ZHANG Hong-xu, HAN Feng, HUANG Jin-yue, LING Xin, LIU Guang-feng. Correlation between Activity of T Lymphocyte Subsets and NK Cells and Antibiotics Use in the Cancer Patients[J]. Chinese Journal of Pharmacovigilance, 2016, 13(11): 645-650.

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