Abstract: Objective To observe the difference in antipyretic effects between living rhino horn and rhino horn by the comparative research method. Methods The antipyretic effect of the living rhino horn was evaluated in rabbit fever model by subcutaneous injection of bacterial endotoxin, and in rat fever model by subcutaneous injection of dried yeast. Results The living rhino horn of 50, 100 and 200 mg·kg^-1 significantly reduced the temperature of fever rabbits. The living rhino horn of 220 and 440 mg·kg^-1 significantly prevented the body temperature from rising in rats. There was no significant difference in antipyretic effects between the traditional rhino horn and the living rhino horn at the same dose. Conclusion The antipyretic effect of living rhino horn is equal to that of the traditional rhino horn, and the living rhino horn can be used as a substitute of rhino horn.

Key words: living rhino horn, rhino horn, antipyretic effect , rat, rabbit